Manal Khalid Abdulridha, Luis Chacón – Garcíaa and Andreas Benderb
Department of Clinical Pharmacy Institute of Chemical Biology, College of Pharmacy, AL-Mustansiriyah University, Baghdad, Iraq
Infection with H. pylori is a substantial public health problem that affects 20-50% of people in industrialized nations, and up to 80% in less developed countries. Helicobacter pylori (H. pylori) infection and non - steroidal anti-inflammatory drugs (NSAIDs) have been identified as the main causes of peptic ulcer disease (PUD). It has been shown for many years, that blood group A had been associated with gastric carcinoma, while blood group O have been associated with DU; however no explanation for this association was received. This study was conducted to, first, determine the relationship between ABO blood groups and Rhesus (Rh) factor and H. pylori in patients with peptic ulcer disease in Iraq,and second, to study the efficacy of the two weeks triple therapy in peptic ulcer patients with different blood groups. Atotal of 84 patients who presented with symptoms of PUD and showed positive endoscopic examination of PUD, 88 patients showed evidence of H. pylori by histology and stool antigen test or UBT were included in the study (receive H. pylori eradication therapy). Patients were divided into four groups according to ABO blood group phynotypes: All H. pylori infected patients received triple therapy (clarithromycin (500 mg) capsules, amoxicillin (1g) capsules and esomeprazole (20mg) capsules all given twice daily) for 14 days duration. Patients were followed up by re- endoscopic examination (to determine the efficacy of the treatment) after 2 months of end of treatment. Stool antigen test or UBT was done to confirm the eradication of bacteria.
RESULTS AND CONCLUSIONS