Sefeera A.A. and Junise V.
Department of Pharmaceutics, Al Shifa College of Pharmacy, Perinthalmanna, Kerala, India
Studies were undertaken on the development and characterization of Reconstituted suspension powder of Rifampicin Microspheres, with a view to develop control release formulation. In this preparation, polymers (chitosan & sodium alginate) were used with a fixed concentration of Rifampicin [(1:1:1), (1:1:2), (1:1:3), (1:1:4), (1:2:1), (1:3:1), (1:4:1), and (1:2:2)].Microspheres were prepared by ionotropic gelation technique. All formulations were showed good flow properties. Interaction studies like UV and IR spectra show that there were no interaction between drug and carrier used. SEM and particle size analysis showed that the size of the particles were below 10µm, with sphere in shape and all formulation shows good % yield with good % drug content (75% -96 %,) and %encapsulation efficiency. Formulation 3, shows overall good report, and shows zero-order kinetics with Non-fickian mechanism of drug release. After the evaluation of microspheres, RM-3 was selected for preparing suspension with different concentration of Xanthan Gum, and Evaluation of suspension was showed compatible results, particle size analysis was showed that the range of size is 6.2 µm and with good zeta potential (-69.8 mv) .Drug release study of suspension also shows good release ( 60% - 68%) with 8 hrs.