Department of Pharmacology, Umm AL-Qura Univirsity, Makkah, Saudi Arabia
Intensive efforts and international collaborations have been performed and are still ongoing in the fight to beat cancer, and many successes have been achieved as a result of hardworking scientists. Although cancer still exists, new information is learned every day, and research continues to be published containing new theories and findings. Cancer research is characterized by the use of advanced technologies that play a role in accelerating results, which then translates into clinical practice to improve the concept of personalized medicine. Currently, next-generation sequencing [NGS] is one of the most advanced technologies used in cancer research due to its ability to provide valuable information from genomic sequencing. Not only is it capable of examining genes but it can also detect and target expected mutations in certain clinical situations and find unexpected sequence variations without consuming substantial time or effort; therefore, NGS provides clinicians with a better understanding of cancer mechanisms. This article demonstrates the pharmaceutical applications of NGS, from tumor markers to pharmacogenomics and targeted therapy, precision medicine, vaccinology, biopharmaceutics, polypharmacology, toxgnostics, and pharmacoepidemiology.
Keywords: Next Generation Sequencing, NGS, Cancer, Pharmacogenomics, Precision Medicine, Poly pharmacology, Toxgnostics, Pharmacoepidemiology, Personalized biomarker.