Abdalla M. Jarari, Ayman S. Abdelsalam, Nouh M.H. Aljarari, Awad M. Abdelstar Alhasnony, Osama Hussein Al Deeb and Peela Jagannadha Rao
Faculty of Medicine, Quest International University Perak, 227 The Teng Seng Level 2, Jalan Raja Permaisuri Bainun, 30250 Ipoh, Malaysia
Background: Sevoflurane is an inhalation anaesthetic agent for use in induction and maintenance of general anesthesia. Administration has been associated with a smooth, rapid loss of consciousness during inhalation induction and a rapid recovery following discontinuation of anesthesia. Minimum alveolar concentration (MAC) of sevoflurane in oxygen for a 40 year old adult is 2.1%. The present study to evaluate liver function of the patients who underwent sevoflurane anaesthesia for long time.
Material and Methods: In this prospective study 20 patients were selected from Tabruk Medical Center, Tabruk, Libya who were undergoing surgery with Sevoflurane as anaesthetic. All the patients were analyzed Aspartate aminotransferase, Alanine aminotransferase, Lactate dehydrogenase, alkaline phosphatase, and Total bilirubin was measured by authenticated methods pre operatively and 1 and 2 nd day of postoperatively.
Results: Aspartate aminotransferase level significantly elevated on 1st postoperative day (p-value 0.001) and on 3rd postoperative day (p- value 0.012) as compared to preoperative value. Alanine aminotransferase level increased significantly on the 1st postoperative day (p- value 0.001) and on 3rd day postoperative day (p. value 0.003).Alkaline phosphatase decreased significantly in 1st postoperative day (p-value 0.001) and on 3rd postoperative day (p-value 0.309).lactate dehydrogenase was decreased significantly in 1st postoperative day (p.value0.004) and on 3rd postoperative day (p. value 0.017). Serum total bilirubin level was increased significantly on the 1st postoperative day (p. value 0.001)and on 3rd postoperative day (p. value 0.028).
Conclusion: According to this study the liver enzymes and bilirubin were raised but not above reference range. Hence long duration anesthesia by sevoflurane is relatively safe and not hepatotoxic.