Anuradha Mishra and Vikal Tripathy
School of Vocational Studies and Applied Sciences, Gautam Budhh University, Gautam Budhha Nagar-201310, India
Interest in plant based excipients for drug delivery systems is increasing day by day owing to their biodegradability and nontoxiciy. In this endeavour, various naturally derived polymeric materials have been tried as an excipient for drug delivery. Some commonly used plant based excipients are psyllium husk, pectin, lin n, mucilage from pods of Hibiscus esculanta, gaur gum, konjac gum, cassia seed gum and tamarind seed gum.
Tamarind fruit is a well known cost effective agro-based material used mainly in food industry. The mucilage obtained from the seeds of Tamarindus indica, an agricultural byproduct, is chemically a xyloglucan. Tamarind seed polysaccharide (TSP) possesses mucomimetic and pseudoplastic properties also. Its ‘mucin-like’ molecular structure is similar to corneal and conjunctival mucin. It has been reported in various studies in-vitro as well as in-vivo that xyloglucan can be used as an efficient excipient. TSP becomes a suitable material to be used as stabilizer, thickener, gelling agent and binder and as an excipient in hydrophilic drug delivery system due to its remarkable properties that have been investigated in detail such as high viscosity, broad pH tolerance muco-adhesivity, non-carcinogenicity, high drug holding capacity, biocompatibility and high thermal stability.
This article reviews the evidences that favor the use of TSP in the development of an effective drug delivery excipient and to show the advantages gained from using TSP and materials based on it.
Keywords: Drug delivery system, Xyloglucan, Tamarind seed polysaccharide.