Invited Speaker

Bio-immunotherapy a combined bilogical and immunological cancer therapy modality
Thomas Tallberg
Finland

Tumours may spontaneously regress which implies that mammals possess a natural intrinsic regulatory capability to control the de-differentiation of specialized organ cells, "The metabolic triumph of the host" (Dr. W.M. Cole 1974). Thus a novel paradigm is that cancer represents a complex chronic metabolic deficiency disease which can be compensated by biological dietary means.

The aim was consequently to analyze if the disturbed interior milieu can be corrected I compensated and lead to a biological cure without side-effects. In randomized clinical studies with hundreds of cancer patients, over 30 years, highly significant (p=0.001) improvement in the survival rate have been obtained by feeding them a specific combination of nutritional amino acids, trace-element ions, inductional central nervous system lipids (CNS), supporting the hormonal balance, and by specifically activating the patients autologous irnmune-defence. The composition of these natural aetiological biomodulating factors regulating our three major forms of cancer; leukemia, adenocarcinoma, and sarcoma have primarily been outlined [Fig 1). Clinical results are usually further improved if the therapy is combined with active specific immunotherapy utilizing polymerized autologous tumour tissue. Tumour tissue should therefore be saved at surgery to facilitate the preparation of individual vaccines, since patients' malignant cells contain a fingerprint of antigenic tumour-markers (J Biol Chem 1967:242;1651-1659). In bio-immunotherapy significantly better disease-free intervals were achieved utilizing powders containing these vital dietary supplements, for years, correcting this complex aetiological metabolic deficiency causing cancer, regaining the internal healthy balance. A randomized study with 127 patients suffering from metastasized renal cancer dietary supplements could also arrest recurrent disease. Pertinent bio-modulating dietary components were; L-amino acids; Ala, Arg, Asp, Lys, + trace-elements; Cr, Mo, Se, Sn, V, and central nervous system CNS-lipids, & physiologic doses of vitamins. Significantly improved clinical results were also obtained with cutaneous (102 cases) and uveal melanoma (54 patients) ingesting; Gly, Glu, Ala, Asp, Ile, Lys, + Cr, Se, Sn, V, W, & CNS-lipids. Ready-made powders compiled to treat prostate cancer are obtainable from our Institute, at a cost of only 2-4 €/ day (Int J Biotechnology 2007: Vol. 9, 314; 391-410). In renal cancer significant improvement has been achieved from dietary correction alone (p=0.04), with high risk (T3) uveal melanoma (p=0.001). Good therapeutic results have also been obtained with other forms of cancer (J Austr Coll Nutr & Env Med 2003:22 No.1; 1-20). This healing reaction does not involve apoptosis or lysis of tumour cells as they regain normal function with complete regression (CR), even of big tumours, without a scar. Regular immune reactions do not have such a capacity. Actually activated regulatory organ-specific mitochondria (cell type specific) have been found to be involved in the healing process. Metabolic bio-modulation can also prevent recurrent cancer as it actively strives to correct the aetiological deficiency. Our standard therapy is primarily extracting only symptoms of this metabolic deficiency disease. It is as if only the loose teeth of a scurvy patient were removed instead of giving him vitamin-C. Malignant transformation caused by genetic weaknesses (e .g. HNPCC) is out of reach for gene therapy, since it involves aberrations in several genes, but malignant transformation can be prevented by dietary supplementation administering small amounts of pertinent essential metabolic components aimed to sustain the physiologic internal milieu. in the patients' body. Healthy persons attain this balance from their normal diet. All bio-modulating components involved are natural substances, and thus ethical, inexpensive, easy to administer, and have a long shelf life. Bio-immunotherapy entails no side effects, but harbour also prophylactic potentials.