Poster Presenter

Potential of Niosome as Antibiotic Delivery System to Bacterial Biofilms
Ali Mohammadi Bardbori, Hamid Reza Mirzaei, Hadi Dibaj, Mohammad Eghbali, Motahareh Mirzaei

The conventional view of antibiotic resistance is one where bacteria exhibit significantly reduced susceptibility to antimicrobials in laboratory tests by mechanisms such as altered drug uptake, altered drug target, drug inactivation and biofilm formation. Growth as a biofilm almost always leads to a significant decrease in susceptibility to antimicrobial agents compared with cultures grown in suspension and, whilst there is no generally agreed mechanism for the resistance of biofilm bacteria, it is largely phenotypic. A number of elements in the process of biofilm formation have been studied as targets for novel drug delivery technologies. At present, no available drug delivery system achieves the site-specific delivery. Herein, for first time, it would be speculated the potential of niosome as a system for antibiotic delivery and targeting of bacterial biofilms. Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic molecules. Niosomes are promising vehicle for drug delivery and being non-ionic; it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. The hydrophilic core of molecule provides an ideal domain for hydrophilic drugs. In addition, lipophilic compounds can incorporate into hydrophobic domain. In addition, modification of noisomes can direct them to specific targets. Niosomal system can target antibiotics to the surface of bacterial biofilms, or by virtue of their property of being taken up cells of the reticuloendothelial system, to target antibiotics towards intracellular bacteria.