Poster Presenter

Biomimetic Aromatization Of Hantzsch 1,4-Dihydropyridines By L-Cystine/SiO2
Hamid Aliyan and Maryam Khosravi
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Hantzsch 1,4-dihydropyridines (1,4-DHP), analogues of NADH coenzymes have received most attention because of their relevant applications in various cardiovascular diseases. In addition, recently preceding studies have suggested the 1,4-DHP derivatives also provide an antioxidant protective effect that may contribute to their pharmacological activity. This effect is not due to the Ca2+ antagonist effect, but is related to the reactivity of these compounds towards radical series. On the other hand, the oxidation of the dihydropyridine ring is the main metabolic route for these compounds.

In the human body these compounds are oxidized to pyridine derivatives by the action of cytochrom p-450 in the liver.

The oxidative aromatization of 1,4-DHPs to the corresponding pyridine derivatives constitutes the principle metabolic route in particular in biologically significant NADH redox processes, as well as a facile access to the corresponding pyridine derivatives, which show antihypoxic and antiischemic activities, from the easily available 1,4-DHPs.

In continuation of our studies on the oxidation of 1,4-DHPs with diphenyl disulfide in ionic liquid we found that L-Cystine/SiO2 are a oxidizing compound for oxidative aromatization of DHPs to the corresponding pyridine derivatives.