Poster Presenter

Highly Efficient Synthesis of Dihydropyrimidines, Bis-Indolylmethanes and 1,5-Benzodiazepines in the Presence of Cu3/2PMo12O40/ Zirconium Phosphate (ZrP) as a Green and Reusable Catalyst
Razieh Fazaeli, Hamid Aliyan

The synthesis of dihydropyrimidinones is currently important because of their wide range of pharmaceutical and biological properties. Particularly, aryl 3,4-dihydropyrimidinones are found to exhibit a wide spectrum of biological activities such as antiviral, antitumor, antibacterial and anti-inflammatory behavior. Indol derivatives are known to possess various biological properties including antibacterial, cytotoxic, antioxidative and insecticidal activities, many indole derivatives are used as antibiotics in pharmaceuticals. Benzodiazepines are interesting compounds because they belong to an important class of the pharmacologically pre-eminent 1,5-benzodiazepines which have been extensively used as anticonvulsant, antianxiety, analgesic, sedative, antidepressive and hypnotic, and antiinflamatory agents. In addition, 1,5-benzodiazepines are valuable synthons used for the preparation of some fused ring benzodiazepine derivatives for the preparation of other fused ring compounds such as triaxolo-, triazolo-, oxadiazolo-, oxazino- or furano-benzodiazepines.

The efficiency of Cu3/2PMo12O40/ ZrP as well-known solid acids is investigated for the three-component condensation reaction of an aldehyde with b-ketoester and urea in acetonitrile to afford the dihydropyrimidinones (DHPM). Cu3/2PMo12O40/ ZrP, were also found to be efficient catalyst for preparation of other heteroatom compounds including 2,3-dihydro-1H-1,5-benzodiazepines and bis-indolylmethanes at room temperature under solvent-free conditions. These method are easy, rapid, and high yielding reaction for the synthesis of Biginelli compounds, bis-indolylmethanes and 1,5-benzodiazepine derivatives. The catalyst can be easily recovered and reused for several times in all above studied reactions without loss of its activity.