Poster Presenter

Drug Utilization Evaluation of Antibiotics in Orthopedics Surgery in a Hospital in India
Neetu Malik, Avijit Mazumder, Debarati Mazumder

Background: Antibiotic resistance, a major consequence of antibiotic overuse, is an important problem worldwide. The Intensive care unit (ICU) is a setting where a large number of drugs are administered to patients & chances for drug errors are high.

Objectives: To assess the pattern of antibiotics usage in the Intensive care unit (ICU) & High dependency unit (HDU) in a hospital in New Delhi (India).

Methods: A retrospective analysis (qualitatively and quantitatively) of the patients admitted to the ICU & HDU was conducted for a duration of four months. The present study was carried out to obtain basic demographic information of patients i.e co-morbid, H/O allergy, past surgery, drug utilization during the study period, outcomes, duration of hospitalization, time taken in surgery, culture sensitivity reports, age, sex, weight distribution of patients were also studied, empirical or definitive therapy and to measure antibiotics consumption monthly.

Results: Out of 111 patients who have been admitted during the study period, 60(54.05%) male & 51(45.95%) female were audited. 50.45% of patients were above 55 years & 72.07% of patients were above 60 kg. The average mean duration of hospitalization was 6.29±4 days. E.coli, P.aeruginosa were the common organism isolated from the infected patients. The average exposure of patients to antibiotics for prophylaxis was 1.79±0.43, for treatment was 2.04±0.86, on discharge 1.18±0.39. 88.29% of patients were given empirical; 11.71% were given definitive therapy. Frequently prescribed antibiotics or their combination were cefuroxime, cefuroxime+ tobramycin. Consumption of cefuroxime was maximum followed with tobramycin.

Conclusion: The use of antibiotics on empirical basis was a routine prescribing practice. Second generation followed by third generation cephalosporins are the most popular antibiotics in combination with aminoglycosides. The study finding call for a periodic review of drug utilization evaluation of antimicrobials in the ICU & H DU.