Poster Presenter

Hypolipidemic Effect of Psidium guajava Raw Fruit Peel in Diabetic Rats
Shikha Mehta, Geeta Watal, Prashant Rai

Background and Objective: The study aimed to evaluate the hypolipidemic potential of unripe Psidium guajava fruit peel aqueous extract in streptozotocin (STZ) induced severely diabetic rats by assessing their Triglyceride (TG), Total Cholesterol (TC), High Density lipoprotein (HDL), Low density lipoprotein (LDL), and very low density lipoprotein (VLDL) levels.

Method: Severely diabetic albino Wister rats of same age group were treated orally once a day upto 3 weeks with a dose of 400 mg/kg bw of lyophilized extract. TG, TC and HDL levels were estimated using standard kits of Bayer diagnostics, India. LDL and VLDL cholesterol levels were calculated from the above measurements by using Friedwald formula.

Results: A significant decrease in TG (P< 0.01), TC (P<0.01), HDL (P<0.01) VLDL (P<0.001) and LDL (P<0.01) levels was observed after 21 days treatment.

Interpretation and conclusion: The extract showed significant hypolipidemic activity in addition to its hypoglycemic and antidiabetic activity reported earlier by our research group (). In view of its hypolipidemic, hypoglycemic and antidiabetic activity Psidium guajava raw fruit peel may be developed as an antidiabetic agent.