Poster Presenter
Antidiabetic and Antioxidant Activity of Swietenia mahagoni
in Streptozotocin-Induced Diabetic Rats
Siva Prasad Panda, Pallab K Haldar, Samit Bera,
Soumitra. Adhikary, Upal K Mazumder, Chandi C Kandar
In the present study, antidiabetic activity
of methanol extract of bark of Swietenia mahagoni L. Jacq.
(MESM) (Meliaceae) in streptozotocin (STZ) 65mg/kg body weight (b.w.)
induced diabetic rats was evaluated. Intraperitoneal administration
of MESM at the dose of 25 and 50mg/kg b.w. results significant (p<
0.001) reduction in blood glucose levels in diabetic rats. The blood
glucose levels and body weights were measured on every 5th
day over a period of 15 days. Body weights were significantly (p<
0.001) reduced in STZ-induced diabetic rats when compared to normal
rats, while the extract significantly restored body weight. Glibenclamide
(0.5 mg/kg; orally) was taken as reference drug. The present study
was further undertaken to evaluate antioxidant activity of MESM in
STZ-induced diabetic rats. The decreased levels of thiobarbituric
acid reactive substances (TBARS), increased levels of glutathione
(GSH) and catalase (CAT) activity indicating the reduction in the
free radical formation in tissues such as liver and kidney of the
diabetic rats. This finding showed the significant hypoglycemic and
antioxidant activity of the extract in diabetic rats.
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