Poster Presenter

Correlation Of Pharmacokinetic Parameters And Lipophilicity Of Some Cephalosporins
Natasa Jevrem Janjic, Eric Slavica, Danica Agbaba, Nada Perisic-Janjic
Serbia

Lipophylic character is important physicochemical parameter of a molecule, which ordered the biological activity of compounds.

Lipophility play an important role in the transport of compounds through a biological system and it may also influence the for- mation of complex between a compound and receptor or biomacromolecule.

In this work we investigated the correlation between lipophilicity expressed by experimental determi- ned retention constants,RM0,(RP C18- HPTLC) and pharmacokinetic data-Half life, and ChemSilico predictors: Plasma Protein Binding Predictor (CSPB), Blood-Brain Barrier Partition Predictor (CSBBB) and Human Intestinal Absorption Predictor (CSHIA).

The compounds investagnated are relatively easily absorbed, they bind with plasma proteins in great percentage. High significant relationship between, retention constants constants, RM0, ( RP C18-HPTLC) and ChemSilico Plasma Protein Binding Predictor was recorded.

Retention constants, as measure of lipophilicity, is well correlated with biological activity ID50. Results show that retention constants can be used as measure of lipophilicity of compounds investigated. These investigations can be used as model of an early phase of drug discovery.