Poster Presenter

The Anti-Tumor Effects of Caffeic Acid Solid Lipid Nanoparticle on 5RP7 Cell Line
L.Genç, H.M. Kutlu, G. Güney, A.İşcan
Turkey

Caffeic acid (CA) is a widespread phenolic acid that occurs naturally in many agricultural products such as fruits, vegetables, wine, olive oil, and coffee. It is also known as an antioxidant in vitro. Caffeic acid and its derivatives are used as a component of antimitogenic, anticarcinogenic, anti-inflamatory, and immunomodulator.

Solid lipid nanoparticles (SLNs) have been introduced as an alternative drug carrier system to traditional drug delivery. Solid lipid nanoparticle have been numerous advantages. Such as; they can protect labile compounds from chemical degradation and provide a targeting effect to improve the efficiency of the drug. SLNs were prepared by homogenization method. Compritol® was used as the lipid. For the characterization of the formulations obtained, particle size distribution, Zeta potential measurement, thermal behavior (DSC), active agent content and pH were investigated.

We postulated that, caffeic acide solid lipid nanoparticle interaction with rat embryo fibroblast cells, 5RP7. We examined the cytotoxic effects of SLN caffeic acid, again on 5RP7 cells and determined cellular and ultrastructural of 5RP7 cell by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), TEM.