Poster Presenter

Modified siliceous mesoporous materials as carriers for drugs with continuous prolonged evolution
Marek Laniecki, Michal Moritz, Marek Laniecki
Poland

Siliceous mesoporous materials of SBA-15 type with uniform dimensions of the pores (usually 6.5 nm) and possibility of engineering of their dimensions, were applied as supports for metoprolol, papaverine, theophylline and ketoprophen. Internal space of the SBA-15 ( ~ 1 cm3/g), with siliceous walls functionalized with (3-aminopropyl)triethoxysilane or (3-mercaptopropyl)trimethoxysilane, was loaded with different amounts of described drugs. Strong interaction between basic surface of the carrier and ketoprophen and theophylline resulted in linear drug liberation with almost zero order kinetics. Similar effect was found for acidic surface (after functionalization with 3-mercaptopropyltrimethoxysilane) loaded with metoprolol and papaverine. Application of mesoporous siliceous materials as drug supports can lead towards simplified methods of drug formulation with prolonged action. It was proved that appropriately modified siliceous mesoporous materials can serve as the excellent supports for drugs. Moreover, the SBA-15 loaded drugs exhibited prolonged time of evolution during 24 hours. In all studied cases almost the zero kinetic order of drug evolution was observed.