Poster Presenter

Advanced Penile Verrucous Carcinoma Treated With Intra-Aortic Infusion Chemotherapy.
MC sheen, HM Sheu,MY Jang CY, YW Wang, CF Wu.
Taiwan

Purpose: Traditionally, the treatment for advanced penile verrucous carcinoma is penectomy. This mostly leads to remarkable psychosexual problems and greatly affects the quality of life especially in young patients. In order to preserve the penis, intra-aortic infusion chemotherapy was used in advanced verrucous carcinoma .

Materials and Methods. From 1991 to 2009 6 cases of penile verrucous carcinoma were treated by continuous intra-aortic infusion with methotrexate (50mg) every 24hrs, for an average of 11 days. Citrovorum factor (6mg) was given intramuscularly every 6 hours during the period of methotrexate infusion.

Results: After treatment, four patients achieved complete remission. They are all living disease free from17years10months, to 3 years9months after therapy. Partial responders subsequently received penectomy. One case developed transformation to squamous cell carcinoma with inguinal metastases and died.

Conclusions: Intra-aortic infusion chemotherapy is a simple and effective method for penile verrucous carcinoma with the uniqueness of preservation of anatomical structure, sexual function and fertility for the complete responders. For penile verrucous carcinoma especially in younger patients, intra-aortic infusion chemotherapy may be considered as an organ-sparing treatment before penectomy is carried out.