Poster Presenter
Ultrasonic Loading Technique
for Candesartan has Better Efficiency than Ionic Gellation
A. Gecer, N. Yildiz, B. Turan and A. Calimli
Turkey
An antihypertensive drug candesartan(C24H20N6O3)
was loaded to trimethyl chitosan nanoparticles by ionic gellation[1]
and ultrasonic effect[2] techniques. The efficiencies of candesartan
loading were compared for these two techniques by using FTIR and
HPLC analyses. The chemical interactions between trimethyl chitosan
nanoparticles and candesartan were investigated by FTIR
analyses. The loading efficiencies of the candesartan loaded trimethyl
chitosan nanoparticles were determined by HPLC analyses. The ultrasonic
effect technique was found better than ionic gellation technique
according to loading efficiency values.
The authors are thankful to Ankara University Scientific Research
Project (Project no:20080745003HPD) and AstraZeneca (Istanbul, Turkey
and Mölndal, Sweden) for a generous gift of candesartan
References:
1. M. Amidi, S. G. Romeijn, G. Borchard,
H. E. Junginger, W. E. Hennink, W. Jiskoot, Journal of Controlled
Release, 111, 107-116, 2006
2. D. Kim, Y. Jeong, C. Choi, S. Roh, S.
Kang, M. Jang, J. Nah, International Journal of Pharmaceutics, 319,
130-138, 2006
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