Poster Presenter

Efficacy Of Hydroalcoholic Extract Of Rheum Ribes L. In Treatment Of Major Depressive Disorder
Mehdi Sayyah Bargard, Hatam Boostani, Siroos Pakseresht , Alireza Malaieri
Iran

Aim of the study: Traditionally Rheum ribes L. has been used in Iran as sedative and mood enhancer. This study investigated the efficacy and safety of a hydroalcholic extract of Rheum ribes in treatment of mild to moderate major depressive disorder.

Materials and methods: Thirty three patients were randomly assigned to receive either Rheum ribes hydroalcoholic extract (1200 mg/day) or placebo in a 6-week, double blind, and parallel-group trial. Patients were assessed before the study and during weeks 1, 2, 4, and 6 by the Hamilton Rating Scale for Depression (HAM-D), and a score sheet on adverse effects.

Results: In week 4 and 6, the extract showed a significant superiority over placebo in reducing depressive symptoms. There was no significant difference between the two groups in terms of adverse effects.

Conclusion: The results suggest that Rheum ribes hydroalcoholic extract has some anti depressive effects. However, further studies are needed to confirm these findings.