Poster Presenter
Evaluation Of Gum Against Cutaneous Leishmaniasis In Mice
Mojtaba Taran, Nadia Asadi
Canada
Leishmania major causes zoonotic cutaneous leishmaniasis
(ZCL) in many rural areas of Iran. CL can be associated with significant
morbidity and occasional deforming scars. Recent circumstantial evidences
are suggesting that an increasing number of Iranian patients with
cutaneous leishmaniasis are unresponsive to meglumine antimoniate
(Glucantime®). Pistacia atlantica
is native plant in Iran (central, western, and eastern regions). Gum
obtained Pistacia atlantica has been reported to possess
considerable in vitro antimicrobial activity.
Male BALB/c mice were inoculated subcutaneously 2 × 106
L. major promastigotes (MHROM/IR/75/ER) at the base of tail. Mice
were randomly divided into 3 groups. in group 1 Glucantime®
was administered to the BALB/c mice in regimen of 60 mg per kg of
body weight for 28 days by intraperitoneal injections per day, in
group 2 the Gum of Pistacia atlantica var. kurdica
were tested by rubbing of local lesions for 28 days, group 3 infected
but non-treated.
Topically rubbing administration of Gum obtained Pistacia atlantica
var. kurdica daily for 28 days like Glucantime®
decreased skin lesion size in the BALB/c mice infected with L.major
compared with that in the control(p<0.01). Treatment BALB/c mice
with Gum obtained Pistacia atlantica var. kurdica
and Glucantime® causes decrease
number of parasitologicaly positive mice(p<0.05).
Our results shows that Gum obtained Pistacia atlantica var.
kurdica can be used for controlling cutaneous leishmaniasis caused
by L.major and inhibiting development of cutaneous leishmaniasis
lesions.
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