Poster Presenter

Resveratrol Analogue Hydroxy Substituted 2-phenyl-naphthalenes Treatment Overcomes the Resistance Conferred by Bcl-2
S. Song, Hongsuk Suh

Resveratrol, a hydroxystilbene present at high concentrations in grape seeds and red wine, was recently shown to have a wide range of biological and pharmacological activities including as a potent antioxidant. Bcl-2 protects cancer cells from the apoptotic effects of various chemotherapeutic agents. Inhibition or down regulation of Bcl-2 represents a new therapeutic approach to bypass chemoresistance in cancer cells. Previously we designed and synthesized the resveratrol analogue HS compound displaying stronger antitumor efficacy than resveratrol and further demonstrated the HS compound resistance conferred by Bcl-2 in human leukemic U937 cells. Various apoptosis assessment assays demonstrated that HS compound overcomes the resistance conferred by Bcl-2 in Caki-1 cells by inducing apoptosis.