Poster Presenter

Prevention of the metabolic complications of the obesity in infant Zucker rats (ZDF) by melatonin
Ahmad Agil, Rosario Ruiz Requena, Jesús Cantero, Miguel Navarro-Alarcón
Spain

Objective: Evaluation the protective effects of melatonin towards the metabolic complications in infant obese rats Zucker (ZDF).

Methods: six groups were studied: three groups of male infant obese ZDF rats (untreated ZDF, vehicle, melatonin) a model of rodent with genetic obesity and that develops to laboratory diabetes the type 2 and their lean littermates. The vehicle or the melatonin (10 mg/kg/day) was given to treatments groups with the drink water, from the 6 - 7 weeks to 11 - 12 weeks, where have been measured, lipid profile (TG, HDL-chol, LDL-chol); glucose levels; inflammatory profile (IL-6).

Results: Melatonin significantly lowered (prevented) significantly the higher dyslipidemia profile levels (TG = 678 ± 21,6 vs 496 ± 64.6 (27%), LDL-chol = 4,22 ± 1.0 vs 2.14 ± 0.9 (50%), HDL-chol = 60,8 ± 13,2 vs 80,2 ± 10,1 (32%), the greater adipogenic profile levels; glucosa = 468,6 ± 39,9 vs 365.0 ± 36 (22%), and insulin levels, that occurred in ZDF compared with levels seen in treated ZDF rats. however, total cholesterol and IL-6 levels were similar in all groups.

Conclusion:melatonin ameliorates dyspidemia, glycaemia levels in ZDF.