Poster Presenter

Nebulized Beclomethasone- Dipropionate Lipidic Nanoparticles
Chiraz Jaafar-Maalej, Laurent Vecellio, Abdelhamid Elaissari and Hatem Fessi
France

The purpose of this study was the formulation of lipid nanoparticles (LN)suspension, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), suitable for beclomethasone dipropionate (BDP) administration via the pulmonary route. LN were prepared by high-shear homogenization method. Then prepared nanoaparticles were characterized in terms of morphology, size, encapsulation efficiency, in vitro drug release and aerosol aerodynamic properties. Nano-sized BDP-loaded LN with high entrapment efficiency values reaching 99% were successfully obtained. Application of in vitro drug release data to the Higuchi kinetic equation indicated a diffusion-controlled release from the lipidic matrix. Aerosolisation and subsequent cascade impaction measurements proved that SLN and NLC were efficiently nebulized yielding aerosols of a suitable particle size for BDP deep lung delivery. Aerodynamic data were used for aerosol deposition prediction in vitro by applying two mathematical models (LUDEP, MPPD).

Accordingly, LN may be considered as promising nebulized carriers for BDP and open the way for new lipophilic drug-targeting systems by nebulization.