Poster Presenter

Preparation of Surface-Modified Poly (Ethylene Glycol) (PEG) Magnetite Nanoparticles
Kobra Rostamizadeh, Hassan Karami, Mehrdad Hamidi, Zahra Bastami
Iran

The goal of this research was to synthesize magnetic polymeric nanoparticles (MPNPs) under 100 nm in diameter, for rug delivery applications. In recent decades, use of magnetic micro and nanoparticles with appropriate surface has been widely studied in many applications such as extraction, pre-concentration, tissue repairing, adjust release medicine and drug delivery. Nano-magnetite particles (ferrofluid, Fe₃O₄) were prepared by chemical co-deposition method and surface-modified with poly (ethylene glycol) (PEG), to improve drug loading and their intracellular uptake. Magnetite nanoparticles can be connected to drugs by hydrogen bonding or physical interactions so that it can be used as a carrier for different drugs. Lisinopril was entrapdeded in the magnetic nanoparticle during preparation. PEG-modified ferrofluid were characterized in detail by fourier transform infrared spectroscopy (FT-IR), SEM, XRD, Malvern Laser Particle Sizer, 1H-NMR, and GPC. SEM studies showed that the magnetite nanoparticles are 50 nm in diameter and XRD patterns revealed that the synthesized magnetite was pure. To optimize drug loading, the influence of some experimental parameters, such as weight, solution pH, initial volume, centrifuge speed and centrifuge time, magnetite dosage in the preparation system, and concentration of the external aqueous phase were investigated. Lisinopril concentration in the solution was calibrated by UV-visible absorbance. The in vitro drug-release behavior of PEG-functionalized magnetic nanoparticles was characterized by two stages involving an initial rapid release, followed by a controlled release. The results showed that surface-modified poly (ethylene glycol) (PEG) magnetite nanoparticles have a typical release behavior.