Poster Presenter

The Effect of Annona squamosa Linn in Dexamethasone Induced Diabetes Mellitus
Sundarapandian Ramkanth, C.Madhusudhana Chetty, M.Alagusundaram, S.Angalaparameswari, K.Gnanaprakash, V.S.Thiruvengadarajan, T.S.Mohamed Saleem
India

An investigation was made to evaluate the role of Annona squamosa L. leaf extract in the regulation of dexamethasone-induced type 2 diabetes mellitus in female rats. In dexamethasone-treated animals (10 mg/kg s.c daily for 10 days) an increase in serum concentration of glucose, triglycerides, LDL, and cholesterol and decreased level of HDL was observed. Animals treated with an equivalent amount of dexamethasone for a similar period when received the leaf extract (300 mg/kg b.w), a decrease in the concentration of both serum glucose, triglycerides, LDL, and cholesterol and an increased level of HDL were observed, indicating the potential of the plant extract in the regulation of dexamethasone-induced diabetes. In conclusion, The methanolic extract showed significant anti-diabetic effect in rats after oral administration at a dose level of 300 mg/kg. Thus the claim made by the traditional Indian systems of medicine regarding the use of this plant in the treatment of diabetes stands confirmed. The results suggest the presence of biologically active principle flavonoids which may worth after further investigation and elucidation.