Poster Presenter

SYNTHESIS OF DRUG-BIODEGRADABLE CONJUGATES
Tomasz Han, Józef Utko, Jolanta Ejfler, Lucjan B. Jerzykiewicz, Piotr Sobota
Poland

The Aim Of Our Investigations Is Elaboration Of New Methods For Production Of Biodegradable Polymers Which Undergo Hydrolytic Biodegradation To Harmless Dismissed Or Assimilated By Organism Products. These Polymers Will Be Used For Preparation Of Drug-Polymer Conjugates Unit Through Tying Of Drug With Biodegradable Polymers And To Production Of Other Materials For Medicine And Pharmacy. The Aim Of Such Strategy Is Better Control Of Dosage And Prolongation Time Of Drug Activity.

To Realizing This Project It Is Necessary To Use Appropriate Biodegradable Polymers And Pharmacological Active Substance With Suitable Function Groups, With Linker, Making Possible Its Recognizing Between Themselves. Hydroxyl Or Carboxyl Group Of Active Substance Exemplifies The Part Of Linkers, Which Should Be Set Free Gradually And Direct, E.G. To Infected Cells.

We Describe Our Initial Studies On The Development Of Novel Magnesium And Zinc Initiators [(L2)2mg2bu2] (1) And [(L2)2mg] (2) And [(L2)Zn2et2] (3) Where L2 = Prih Or Welh (Prih = 1.1-Diphenyl-3-(Piperidine-1-Yl)Propane-1-Ol; Welh = (Rs)-1-[2- (Dimethylamino)-1-(4-Methoxyphenyl)Ethyl]Cyclohexanol) And Their Catalytic Behaviors In The Rop Of Lactides. Note That Prih Is Used As A Drug In Parkinson Disease And Welh As A Drug In Antidepression Disease