Poster Presenter

New Oxorhenium(V) Complex with Imidazol [NN] / Hydantion [SN] Mixed Ligand System , and Radiochemical Behavior of its Oxotechentuim(V) Complex Analog
N.S.Al-Hokbany, I.J.Al-Jammaz, R.M.Mahfouz
Saudi Arabia

[ReO(Imz)(Hyd)OH] complex was successfully synthesized by ligand exchange method of oxorhenuim citrate with Imidazole /Hydantion mixed ligand . Geometry optimization of complex has been carried out using DFT at the B3LYP/LANL2DZ functional in singlet state. B3LYP predicated infrared spectrum of geometrical optimized structural using the same level of the theory and the same base set showed good agreement with experimentally observed values. The spin allowed singlet-singlet electronic transition of the [ReO(Imz)(Hyd) OH] complex has been calculated with time dependent density function theory (TD-DFT) and the UV-Vis spectra has been discussed on is basis. The complex has been characterized using elemental analysis and different spectroscopic techniques (IR, UV-Vis, NMR and MS).

At the technetium tracer level (99mTcO-complex) has been synthesized by two methods (99mTc-gluconate as precursor; direct reduction). The radiochemical purity of the complex was over 95% as measured by thin layer chromatography. In vitro studies showed that the complex possessed good stability under physiological conditions. Its partition coefficient indicated that it was a hydrophilic complex. The electrophoresis results showed the complex was cationic. Biodistrbution in mice showed that the complex accumulated in heart uptake (9.53±3.87) % ID/gm at 5 min and good retention (6.37±1.21) % ID/gm at 60 min. One hour after the injection, the heart/liver, heart/lung and heart/blood radioactivity ratios were 0.46, 1.04 and 0.56, respectively. This indicates that the complex might be suitable for myocardial imaging.