Poster Presenter

Polyoxazoline-β-Cyclodextrin Hyperbranched Copolymers as Drug Delivery
Zohre Zarnegar, Javad Safari, mohsen adeli
Iran

A novel class of biodegradable hyperbranched polymers containing poly (2-ethyle-2-oxazolines) (PEOz) and β-cyclodextrin (β-CD) were synthesized for drug delivery system. In this synthetic strategy tosylated β-CD was prepared and it used as macroinitiator for ring opening polymerization of oxazoline monomer and poly(CD-EOz) was obtained. Polymerization was quenched using different molecules and hyperbranched polymers with different properties, such as solubility and loading capacity were obtained. Congo red and Ag nanoparticle were encapsulated by poly(CD-EOz) hyperbranched polymers and were were characterized by 1H NMR, FTIR , UV, differential scanning calorimetric (DSC) and transmission electron microscopy (TEM). The controlled release of guest molecule from hyperbranched polymer/guest molecule complex in vitro condition also investigated.