Poster Presenter

Development and Comparison of Membrane and Microreservoir Type Transdermal Systems Containing Eudragit NE 30D
Sylvia Marton, Alíz Auner, Khaled Omaru, A. Ashour and Zsófia Fenyvesi
Hungary

Producing beads and /or patches modified drug release may be achieved. The combination of two methods may ensure programmed drug liberation. In our study first gels consisted of sodium alginate (SoA), hydroxyethylcellulose (HEC) and hydroxypropylmethylcellulose (HPMC) were used to prepare by ionotropic gelation method beads, placed into films fresh and dried state served as microreservoirs. In situ gelation in calcium chloride containing Eudragit film was applied to produce microreservoir type transdermal patch. The thickness and polymer content was optimized and factors influencing drug release was determined by Jandel 3D program. Comparision of drug liberation from different types of microreservoir systems and films containing API as beads and/or substance was done. The structure changes of in situ produced beads in films before and after dissolution were presented in photos. DSC was used to determine the API moving during the drying of patches. Drug release was measured by in vitro method and the results were evaluated by Korsmeyer-Peppas and Weibull equations. It was found that reservoir type patches showed good flexibility and release followed polymer swelling opposite to patches prepared by conventional method where API delivered by Fickian diffusion (Eudragit patch) or anomalous transport (gel in Eudragit).