transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"> ICDDT2010: The 2nd International Conference on Drug Discovery & Therapy: Dubai, February 1st - 4th, 2010 (PP-0353)
The 2nd International Conference on Drug Discovery & Therapy: Dubai, February 1 - 4, 2010

Poster Presenter

Sulfo Fatty Acids in Allium sativum: A New Potential Drugs

Afshan Siddiq and Valery M. Dembitsky
Russia

Sulfur-containing fatty acids (SFA) are rare in the nature. Several sulfur-containing fatty (carboxylic) acids have been isolated from garlic and produced by some microorganisms. Recently, 1,2 dithiacyclo-pentane-3-carboxylic acid (also known as tetra-norlipoic, and tetranorthioctic acid) was isolated from two varieties of Iranian garlic (Allium sativum var. sativum and Allium ampeloprasum var. holmens) that are cultivated in North of Iran. The 3-(methylsulfinyl)alanine was detected in different onion cultivars (Allium cepa), and is present among free amino acids in two species of Allium sativum var. opioscorodon (hardneck) and Allium sativum var. sativum (softneck). (S)-2-Propenyl-D-cysteine was isolated from garlic (Aomori Prefecture, Japan) after heating from 30 to 65oC. The 3-(allylthio)-propionic acid was detected among the volatile organic compounds from fresh and frozen dried garlic (Allium sativum, collected in South Korea), and in this study. Three hundred and forty Streptomyces species, grown in the presence of DL-methionine, synthesized 3-methylthiopropionic and trans-3-methylthioacrylic acids. Derivatives of 3-methylthiopropionic and trans-3-methylthioacrylic acids, named entadamide A, and B were isolated from the dry seeds of Entada phaseoloides. Entadamide C, together with entadamide A, was isolated from the leaves of Entada phaseoloides. The structure of 4-thia pentanoic (methyl-thiopropionic) acid formed from methionine was also reported.






























 
















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