Poster Presenter
Sulfo Fatty Acids in Allium sativum: A New Potential Drugs
Afshan Siddiq and Valery M. Dembitsky
Russia
Sulfur-containing fatty acids (SFA) are rare in the nature. Several
sulfur-containing fatty (carboxylic) acids have been isolated from
garlic and produced by some microorganisms. Recently, 1,2 dithiacyclo-pentane-3-carboxylic
acid (also known as tetra-norlipoic, and tetranorthioctic acid) was
isolated from two varieties of Iranian garlic (Allium sativum
var. sativum and Allium ampeloprasum var. holmens)
that are cultivated in North of Iran. The 3-(methylsulfinyl)alanine
was detected in different onion cultivars (Allium cepa), and is present
among free amino acids in two species of Allium sativum var.
opioscorodon (hardneck) and Allium sativum var.
sativum (softneck). (S)-2-Propenyl-D-cysteine was isolated from garlic
(Aomori Prefecture, Japan) after heating from 30 to 65oC.
The 3-(allylthio)-propionic acid was detected among the volatile organic
compounds from fresh and frozen dried garlic (Allium sativum,
collected in South Korea), and in this study. Three hundred and forty
Streptomyces species, grown in the presence of DL-methionine, synthesized
3-methylthiopropionic and trans-3-methylthioacrylic acids.
Derivatives of 3-methylthiopropionic and trans-3-methylthioacrylic
acids, named entadamide A, and B were isolated from the dry seeds
of Entada phaseoloides. Entadamide C, together with entadamide
A, was isolated from the leaves of Entada phaseoloides. The
structure of 4-thia pentanoic (methyl-thiopropionic) acid formed from
methionine was also reported.
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