Session Speaker

Hypoglycemic Effect of Myrtaceae Family Plants in Diabetes
Jai-Wei Chang, Ai-Chun Huang, Szu-Chuan Shen, Ming-Chang Wu
Taiwan

Diabetes mellitus (DM) is one of the major diseases that human being eagerly wants to overcome and has been listed as the third most commonly occurred chronic disease by WHO. In Asia and South America, the leaves and fruits from some Myrtaceae plants such as Psidium guajava, Eugenia jambolana and Syzygium cumini may have the potential in curing diabetes. The report pointed out that the water and ethanol extracts of P. guajava leaves showed significant decrease in the plasma glucose level of diabetic rats. The water or ethanol extracts exhibited significant antihyperglycaemic effect in diabetic rabbits in the glucose tolerance test, water extracts is better than ethanol extracts of E. jambolana seeds, and water extracts of S. cumini seeds have significant hypoglycaemic effect in diabetic rats. Based on above study, it confirmed that the three plants for diabetes have significant hyperglycaemic effect. The leave and fruit of Eucalyptus citriodora, Syzygium formosanum Hay, Eugenia uniflora and Leptosperum scoporium were used for to investigating on insulin resistance improvement, proteomics, and hypoglycemic effect in type 2 diabetes. Insulin resistance cell models is used for discussion the carbohydrate metabolism and mechanism by proteomic study, the result show the extraction of these five plants’ leave could improve the abilities of glucose uptake in clone9 liver cells and 3T3-L1 adipocytes. The extraction of Eugenia uniflora had the best effect,and the water extraction was better than ethanol extraction. But these had no effect to improve the abilities of glucose uptake in muscle cell C2C12. Except for improve the abilities of glucose uptake,those could also improve the tyrosine phosphorylation of IRS-1, and the translocation of GLUT4 to the cell membrane in insulin-resistant cells.