Session Speaker

IMH-Based Materials Bind Dietary Phosphate Effectively in vivo
J.J. Powell, C. Hutchinson, N.J.R. Faria, DIA Pereira, P. Winship
UK

Interstitial mineral hydroxides (IMH) are materials that comprise metal oxo-hydroxides doped with biologically compatible low molecular weight ligands, through ligand substitution of oxo/hydroxy groups. IMH have different tailorable physico-chemical properties compared to the parent metal oxide and are being explored by our group for therapeutic applications. In a separate study we have validated, in vitro, the efficacy of adipate-doped iron oxide (FeO-Ad IMH) as a potential therapeutic phosphate binder. Here in 15 volunteers, we have assessed the interaction in vivo between dietary phosphate and FeO-Ad IMH following a single oral dose. Our in vitro model predicted that FeO-Ad IMH would reduce excretion by 117 mg of phosphate and based upon changes to urinary excretion versus placebo we found a reduction of 126 mg phosphate following FeO-Ad IMH. These findings support the in vitro conclusion that FeO-Ad IMH could be a superior therapeutic to current treatments and be efficacious in the binding of dietary phosphate in patients with end stage renal disease.