Session Speaker

Discovery of the New Biotechnological Procedure of Generation and Identification of Thymic Epithelial Progenitor Cells by In vitro Processing of Hyman Thymic Fragments for Allotransplantation – Possible Clinical Application in Aging Carriers
Wozniewicz BM, Janus R, Maruszewski B,Michałkiewicz J,Nawrot I,Sawicki A, Fedorowicz M
Poland


Discovery of the new biotechnological procedure of generation and identification of thymic epithelial progenitor cells by in vitro processing of human thymic fragments for allotranplantation - possible clinical application in aging The new innovative biotechnological procedure of generation and identification of stromal progenitor cells derived in vitro from human thymic fragments culture. (PL patent 378431)has been discovered and described in this paper. Our aim was to prepare material for improving a quality of life in aging be rejuvenation of the dysfunction on immune system by the way of cellular therapy. Previously similar method was discovered in experimental animals. Successful thymus transplantation with immune suppression in children was described in the Di George syndrome. Thymic progenitor cells have a potential to recovery immune system and improve neuronal transmission at the synapses. The procedure was based on the process in which all immunological elements were deleting during organ culture. Finally obtained population consists of pure culture of pTEC devoid of immunogenic antigens. For identification of thymic progenitor cells SDF-1, cytokeratins and other markers were used. The thymic pTEC were experimental successfully transplanted for first into a 72 -year-old volunteer in order to prove that progenitor cells do not induce neither a local nor systemic rejection response.

Thus article and study have been sponsored by the Ministry of Science National Grant No 2135/PO-1/ 2007-2009/32 (Implementation grant competition No 36).