Session Speaker
To Study the Effect of Furosemide on Micellar Behaviour of
Ionic Surfactants - A Physicochemical Approach
S. Chauhan, V.K. Syal, M.S. Chauhan and D. Kaushal
Micellar solubilization is an effective way for the dissolution of
hydrophobic drugs in aqueous environment. Pharmacologically active
compounds, also known as drugs are amphiphilic in nature and can,
therefore undergo different kinds of associations in a surfactant-like
manner. Ionic surfactants are found to be better solubilizing agents
than non-ionic surfactants and amongst ionic surfactants, solubility
is found to be very high in anionic surfactant as compared to cationic
one. Due to clinical importance of Furosemide - a cardiovascular drug,
a large number of analytical methods to detect the presence of this
drug in pharmaceutical and physiological samples using surfactants
have been developed. Critical micellar concentration (CMC) values
for Sodium dodecyl sulfate (SDS) are found to be lowered in the presence
of drug indicating its greater solubility.
In the present work, therefore we provide a concept of micellar solubilization
of drugs in surfactant systems in the concentration range 0.001M and
0.01M of Furosemide with surfactants SDS and Cetyltrimethylammonium
bromide (CTAB) by measuring different transport properties viz : Conductance
measurements of anionic surfactant SDS and cationic surfactant CTAB
have been measured in solutions of aqueous Furosemide (0.001and 0.01M)
in the temperature range 20 – 40ºC.
From these measurements, CMC’s of SDS and CTAB have been determined
in the above said aqueous Furosemide solutions. From CMC data, various
thermodynamic parameters viz. ΔHºm,
ΔSºm
and ΔGºm
have been evaluated. Sound velocity and density measurements are used
to calculate the compressibility coefficient (β),
apparent molar volume (φV)
and apparent molar compressibility (φK).
The viscosity studies of SDS and CTAB have also been included in order
to calculate relative viscosity (ηr).
All these parameters provide insight in terms of drug – surfactant
interactions as a consequence of various electrostatic and hydrophobic
interactions.
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