Session Speaker

Intercorrelations of selected heart parameters after non-treated myocardial infarction in rats and their potential diagnostic relevance for humans
Tadeusz Krzeminski, Robert Podsiadly, Tadeusz F. Krzeminski, Jozef Spalek

In recent years one observes an enormous progress in treatment of patients with a myocardial infarction (MI). However, the relationship between hemodynamic functions and the cardiac remodeling after the MI has not been fully elucidated as yet. Also, the characterization of the actual post-MI heart state is often narrowed down to insufficient number of parameters and by not taking them into account jointly (i.e. by not intercorrelating them in a rigorous mathematical sense). Here, based on experiment with non-treated post-MI rat hearts, we demonstrate by means of the complex statistical analysis, that in order to make a better prognosis, it is indispensable to intercorrelate a number of relevant parameters over an extended period of time, in addition to specifying their time evolution. The well-documented three-stage evolution of the post-MI heart represents a basic finding of our work and should help in singling out an optimal treatment of the post-MI humans.