Session Speaker

Use of Nanoparticle in Temperature Sensitive Liposomal Drug Delivery
Krishna Pal Singh, Prreti Panwar, Bhumika Pandey
India


Liposomes are nonimmunogenic, biodegradable and non toxic in nature hence they are used as drug delivery vehicles. Liposome surfaces are highly flexible and can be made target specific. The main emphases of the current talk is i) fabrication of temperature sensitive and nontoxic nanoparticles for embedding with PEG iii) coating of PEG for liposome stabilization along with nanoparticles iv) encapsulation of drug in liposomes v) biophysical characterization of liposomes vi) determination of drug encapsulation efficiency of liposomes. The sterically stable/ stealth liposomes were prepared by attaching Polyethylene glycol (PEG) and nanoparticles on the liposome surface. Addition of cholesterol and nanoparticles was just not to affect flexibility and fluidity. Albendazole and methotrexate as drugs were used for encapsulation and release. The drug encapsulation capacity and release sensitivity of liposomes was studied by dialysis method. The biophysical characterization of both PEG and nanoparticle coated and uncoated liposomes were done by TEM and UV-Spectroscopy.