Session Speaker
Retrodifferentiation: A Process Of Harnessing Pluripotency Through Cell Surface Receptor Contact Of More Mature Somatic Cells
Ilham Saleh Abuljadayel


Somatic cell reprogramming of differentiated cells into pluripotent stem cells is an emerging field in stem cell biology. The conversion of more committed adult cells into pluripotent stem cell state has been achieved through nuclear transfer or transfection with more primitive cellular components such the cytoplasm of an enucleated oocytes or nuclear material such as transcription factors involved in early ontogeny of embryonic stem cells, respectively. Alternatively, the reprogramming of fully intact more mature somatic cells into a pluripotent stem cell like cells have been noted in response to cell surface receptor ligation or contact of more committed cells using ligands such as monoclonal antibodies, cytokines and a small synthetic compound.

The basic concept behind such reprogramming technologies is the production of pluripotent stem cells capable of correcting or replenishing defective or damaged tissue and organs including the recreation of an entire organism. Invariably, the term used to describe such processes is either dedifferentiation or retrodifferentiation. Herein, this abstract the production of pluripotent stem cells from mature adult cells such leukocyte via a process of retrodifferentiation, is described. Furthermore, the application of autologous Retrodifferentiated stems cell therapy in treating haematological and degenerative conditions' including aging is discussed is discussed.