Ermitas Alcalde, Immaculada Dinarès, Neus Mesquida, Anna Ibañez, M. José García-Celma, Ferran Roigb and Ermitas Alcalde
Pharmacology and Therapeutic Chemistry, Universitat de Barcelona, Spain
Abstract:
In recent years ionic liquids (ILs) are becoming increasingly useful in a widening range of fields in
chemistry leaning toward biology. Both charged counterparts in ILs can be independently modified,
providing tunability in the design of new functional materials as well as pharmaceutical and
biological ingredients, as well as modulating the properties of active pharmaceutical ingredients
(APIs) with novel performance enhancement and delivery options. A simple method to swap the
halide ion of ILs for a broad range of anions, including ibuprofenate, in non-aqueous media has been investigated as a
part of our ongoing research [1,2]. In order to extend our protocol to arylpropionic acids, we herein report the synthesis
of several [bmim][R-CO2] following AER (A¯form) method from selected examp les of non-steroidal anti-inflamatory
drugs (NSAIDs). In addition, the study of the release from hyaluronan-based hydrogels as drug delivery system was
carried out, considering that the high biocompatibility of this natural polysaccharide provides a good candidate for
biomedical and pharmaceutical use.
Acknowledgments: The authors thank to the SCT-UB for the use of their instruments and the AGAUR (Generalitat de
Catalunya), Grup de Recerca Consolidat 2009SGR562.
REFERENCES:
[1] E. Alcalde, I. Dinarès, A. Ibáñez, N. Mesquida, Molecules, 2012, 17, 4007-4027.
[2] E. Alcalde, N. Mesquida, A. Ibáñez, I. Dinarès, Eur. J. Org. Chem., 2012, 298-304.
