Department of Pharmaceutics, Ashokarao Mane College of Pharmacy, Peth-Vadgaon, Maharashtra, India
Abstract:
Present work deals with preparation and evaluation of spherical agglomerates of Aceclofenac with improved physicochemical properties. Spherical agglomerates of Aceclofenac were effectively prepared using acetone, dichloromethane and 0.1 N HCl as good solvent, bridging liquid and poor solvent respectively with different concentrations of polyethylene glycol 6000 in poor solvent. Prepared agglomerates were evaluated for micromeritics properties, flowability, compactibility, packability, solubility and in vitro drug release. Also drug and agglomerates were characterized by X-ray powder diffraction, differential scanning calorimetry and fourier transforms infrared spectroscopy.
Prepared agglomerates were spherical with enhanced fragmentation and less elastic recovery. Particle size, flowability, compactibility and packability of agglomerates were preferably improved for direct compression compared with raw crystal of Aceclofenac. Incorporation of Polyethylene Glycol 6000 at in to raw crystals of Aceclofenac by spherical crystallization technique significantly improved the solubility and dissolution rate drug. X-ray Powder Diffraction and Differential Scanning Calorimetry study were indicated slight amorphization of drug during recrystallization but not associated with any chemical transition indicated by Fourier Transforms Infrared Spectra. The finding of the present research promises a simple, rapid and economic technique for the improvement of tableting properties and dissolution characteristics of Aceclofenac.
