DESIGN AND SYNTHESIS OF NOVEL DUAL ACTING ANTILEISHMANIAL-ANTIMALARIAL AGENTS DERIVED FROM PYRAZOLE
Adnan A. Bekhit, Ahmed M.M. Hassan, Heba A. Abd El Razik, Mostafa M.M. El-Miligy, Eman J. El-Agroudy and Alaa El-Din A. Bekhit
Department of Pharamceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt
Leishmaniasis continues to be a great burden on at least 88 countries from Africa, South America, Asia and Europe. Most available drugs against leishmaniasis are costly, require long treatment regimes and are becoming more ineffective. The search for new effective anti-leishmanial agents is an urgent and a necessity in large parts of the world to control the disease [1,2].
On the other hand, limited number of drugs can be used to treat or prevent malaria. The increased resistance to these drugs is of concern to health practitioners. Newer anti-malarial drugs were discovered in an effort to tackle this problem, but all these drugs are either expensive or have undesirable side effects [3-5].
As a continuation of our ongoing program concerning the discovery of anti-leishmanial and/or anti-malarial agents [1-4], we designed, synthesized and evaluated the dual activity of some pyrazolylpyrazoles as antileishmanial-antimalarial agents.
Keywords: Pyrazole, antileishmanial and antimalarial.