Academic CRO/Industrial Collaborations in Drug Discovery (Track)
ESR STUDIES ON CHARACTERISTIC CHEMICAL EFFECTS OF SOME IRRADIATED ANTIBIOTICS
Saleh M. Abdou, Magdy M. Hassan and S. Ebraheem
Faculty of Applied Medical Science, Jazan University, Saudia Arabia
Most of the characteristic chemical effects of the irradiated solid drugs are not accurately detected by the conventional tests like melting point, ultra violet spectro-photometry. Antibiotics samples were g-irradiated at room temperature with doses ranging from 2 kGy up to 25 kGy. Electron Spine Resonance (ESR) measurements were applied on four types of antibiotics; Amoxycillin, Ampicillin, Dalacin C*, and Spiramycin (AMX, AMP, DAL and SPI). ESR results exhibited the influence of irradiation and storage parameters on the nature and concentration of the trapped radicals. The radical concentration is proportional to the ESR peak height signal also depending on the absorbed dose delivered to the antibiotic samples.
The obtained information about the irradiated radiolytic products was found to verify the radical mechanisms. The information may be used to detect an irradiation treatment on such pharmaceuticals.
Keywords: Drug sterilization, ESR, Ionizing radiation and Gamma-irradiation.