Inflammation and Immunology (Track)


Mohammad Sharif Sharifi

Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia


Urticaria is a kind of skin rash that sometimes caused by allergic reactions. However, chronic urticaria is mainly idiopathic and caused by autoimmune reaction. Acute viral infection, stress, pressure, exercise and sunlight are some other causes of urticaria, it could last a very long time. 
Case: A 52 years old man presented to local medical services with skin rash, bumps and lines on the face with itch and swelling of the eyes.  Cultures for bacteria, mycobacteria and fungi were negative. Treatment commenced with anti histamine diphenhydramine and hydrocortisone 0.05% and later on 0.1% to relieve itching, resulting in sever irritation on the face. The treatment therefore stopped.

The mast cells in the skins and tissues release Histamine and other pro-inflammatory substances in response to the binding of IgE antibodies to high-affinity cell surface receptors. A large number of patients with chronic urticaria develop autoantibodies directed at the receptor FcεRI located on skin mast cells. Hypothetically, if these cells physiologically removed from the skin, the recovery of the irritation should follow soon. Therefore, the wet cupping was performed on the patient with 60-40 small skin incision. Full recovery of the patient achieved after two weeks.