Prof. Roberto Corradini is Associate Professor at the Department of Chemistry of the University of Parma (Italy), responsible for the laboratory for Artificial DNA synthesis, and Coordinator of a National Project on miRNA recognition. His research interest include the synthesis of bioactive molecules with tailor-made supramolecular interactions, in particular modified peptide nucleic acids (PNA), and the development of new diagnostic tools and gene-modulating drugs. He has published 115 peer reviewed paper on international journals and 10 book chapter, and is Editor of one Book (Springer). He is member of the Editorial Board of Chirality (Wiley VCH), of the American Chemical Society (ACS), of the Italian Chemical Society (SCI), and of the Interuniversity Consortium of Structural and Systems Biology (INBB). He has been invited speaker for several International congresses and in private companies, and has been in the Organizing Committee and in the Scientific Committee of several international congresses. Referee for 15 Journals and 2 research institutions.

Selected publications of the last 2 years:

  1. R. Corradini, S. Sforza, T. Tedeschi, F. Totsingan, A. Manicardi, R. Marchelli. Peptide nucleic acids with a structurally biased backbone.  Updated review and emerging challenges Curr Top Med Chem 2011 , 11, 1535-1554.
  2. R. Gambari, E. Fabbri, M. Borgatti, I. Lampronti, A. Finotti, E. Brognara, N. Bianchi, A. Manicardi, R. Marchelli, R. Corradini. Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development  Biochemical Pharm 2011 , 82, 1416-1429.
  3. E. Fabbri, E. Brognara, M. Borgatti, I. Lampronti, A. Finotti, N. Bianchi, S. Sforza, T. Tedeschi, A. Manicardi, R. Marchelli, R. Corradini,  R.  Gambari. miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs Epigenomics 2011, 3, 733–745.
  4. A. Calabretta, D. Wasserberg,, G.A. Posthuma-Trumpie. ,V. Subramaniam, A. Van Amerongen,; R. Corradini, T. Tedeschi, S. Sforza,; D. N Reinhoudt, R. Marchelli, J. Huskens, P. Jonkheijm.  Patterning of Peptide Nucleic Acids Using Reactive Microcontact Printing Langmuir 2011, 27, 1536-1542.
  5. S. Sforza, R. Corradini, T. Tedeschi, R. Marchelli.  Food analysis and food authentication by peptide nucleic acid (PNA)-based technologies Chemical Society Reviews 2011, 40, 221-232.
  6. A. Accetta, R. Corradini, R. Marchelli. Enantioselective Sensing by Luminescence Topics in Current Chemistry 2011,. 300: 175–216; DOI: 10.1007/128_2010_95.
  7. E. Fabbri,A. Manicardi,, T. Tedeschi, S.Sforza,N. Bianchi, E. Brognara, A. Finotti,G. Breveglieri, M. Borgatti, R. Corradini, R. Marchelli, R. Gambari Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs) ChemMedChem 2011, 6, 2192-2202.
  8. E. Brognara, I. Lampronti, G. Breveglieri, A. Accetta, R. Corradini, A. Manicardi, M. Borgatti, A. Canella, C. Multineddu, R. Marchelli, R. Gambari C(5) Modified Uracil Derivatives Showing Antiproliferative and Erythroid Differentiation Inducing Activities on Human Chronic Myelogenous Leukemia K562 Cells Eur. J Pharm. 2011, 672 (1-3), 30-37.
  9. R. Tonelli, A. Mcintyre, C. Camerin, Z. S. Walters, K. Di Leo, J. Selfe, S. Purgato, E. Missiaglia, A. Tortori, A. Astolfi, J. Renshaw, K.R Taylor, S. Serravalle, R. Bishop, C. Nanni, L.J Valentijn, A. Faccini, I. Leuschner, S. Formica, J.S. Reis-Filho, V. Ambrosini, K. Thway, M. Franzoni, B. Summersgill, R. Marchelli, P. Hrelia, G. Cantelli-Forti, S. Fanti, R. Corradini, A. Pession, J. Shipley.  Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy. Clinical Cancer Res  2012, 18,796-807.
  10. A. Manicardi, E. Fabbri, T. Tedeschi, S. Sforza, N. Bianchi, E. Brognara, R. Gambari, R. Marchelli, R. Corradini. Cellular uptake, biostability and anti-miR-210 activity of chiral arginine-PNA in leukemic K562 cells. ChemBiochem 2012, 13, 1327-1337.
  11. R. Corradini, T. Tedeschi, S. Sforza, M.M. Green, R.Marchelli (2011). Control of Helical Handedness in DNA and PNA Nanostructures, in, “DNA Nanotechnology: Methods and Protocols” Giampaolo Zuccheri and Bruno Samorì (eds.), Methods in Molecular Biology, vol. 749, DOI 10.1007/978-1-61779-142-0_6, Springer Science+Business Media.
  12. R. Corradini, T. Tedeschi, S. Sforza, R. Marchelli (2012). Electronic Circular Dichroism of Peptide Nucleic acids and their analogues in “Advances in Chiroptical Methods” (Editors: Nina Berova, Prasad Polavarapu, Koji Nakanishi, and Robert W. Woody) Volume 2. Chapter 2.IV.5, John Wiley and Sons Inc, (United States). Pages 587-614.