Charles J. Malemud received the B.Sc. in Biology from Long Island University Richard L. Connolly College in 1966 and the Ph.D. from the Department of Biology at George Washington University in 1973 in the field of Experimental Pathology. He then pursued postdoctoral studies at the State University of New York at Stony Brook where he studied the effects of the human neutrophil neutral proteinases, elastase and Cathepsin G on sulfated-proteoglycan degradation in cartilage.

Dr. Malemud joined the faculty at Case Western Reserve University School of Medicine in 1977 where he is Professor of Medicine & Anatomy in the Division of Rheumatic Diseases and Senior Investigator in the Arthritis Research Laboratory.

Dr. Malemud’s primary research interests focus on the mechanism(s) by which cross-talk activates multiple intracellular signaling pathways, such as SAPK/MAPK and JAK/STAT in cultured human chondrocytes. The Arthritis Research Laboratory is also particularly interested in how these signaling pathways are activated by pro-inflammatory cytokines, such as IL-1β, IL-6 and TNF-α as well as by soluble mediators, such as monosodium urate crystals, all of which are relevant to inflammatory forms of arthritis, osteoarthritis and gout. Dr. Malemud and his colleagues have published more than 190 peer-reviewed papers, book chapters and reviews primarily in chondrocyte biology, drug discovery for rheumatoid arthritis and osteoarthritis, signal transduction and apoptosis. Professor Malemud is on the editorial board of rheumatology, immunology and musculoskeletal journals.

He is Editor-in-Chief of the Journal of Clinical & Cellular Immunology and serves as an ad hoc member of several NIH review panels.