Makoto OSANAI, Ph.D
Associate Professor
Radiological Imaging and Informatics,
Tohoku University Graduate School of Medicine



Address

Radiological Imaging and Informatics, Health Sciences, 
Tohoku University Graduate School of Medicine
2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575 JAPAN 

Curriculum Vitae

Education:


4/1987-3/1991

Department of Physics, School of Science,
Nagoya University
Degree: B.S. in physics

4/1991-3/1993

Department of Physics,
Graduate School of Science,
Nagoya University
Degree: M.S. in physics
Thesis: The effect of magnetic field in Brownian motion of non-magnetic colloidal particle
Supervisor: Dr. S. Yoshino

4/1993-3/1996

Department of Physics,
Graduate School of Science,
Nagoya University
Degree: Ph.D. in physics
Thesis: The mechanisms of synaptic transmission in frog neuromuscular junction
Supervisor: Prof. H. Kijima

Appointments:


4/1996-5/1998

Department of Physiology,
Kyorin University School of Medicine
Senior Instructor

6/1998-3/2001

Department of Pharmacology,
School of Medicine,
Tokyo Medical and Dental University
Research Associate

4/2001-8/2001

Department of Physiology,
School of Medicine,
Nagoya University
Visiting Researcher

9/2001-3/2007

Division of Electrical, Electronic and Information Engineering,
Graduate School of Engineering,
Osaka University
Assistant Professor

4/2007-3/2009

Division of Electrical, Electronic and Information Engineering,
Graduate School of Engineering,
Osaka University
Associate Professor

4/2009-present

Department of Radiological Imaging and Informatics,
Tohoku University Graduate School of Medicine
Associate Professor

Publications


[Original papers]
Osanai M, Suzuki T, Tamura A, Yonemura T, Mori I, Yanagawa Y, Yawo H, Mushiake H.
Development of a micro-imaging probe for functional brain imaging.
Neurosci. Res. 75: 46-52, 2013. [Elsevier]

Mori I, Machida Y, Osanai M, Iinuma K
Photon starvation artifacts of X-ray CT: their true cause and a solution.
Radiol. Phys. Technol. 6: 130-141, 2013. [Springer]

Kikuta S, Tamura A, Kikuchi K, Yanagawa Y, Mori I, Osanai M
The spontaneous calcium transients lead to opening the store operated channels in the striatal cells.
Bull. Sch. Health Sci. Tohoku Univ. 21: 77-86, 2012. [TOUR]

Osanai M, Yaguchi Y, Yamada N, Oboshi F, Yagi T.
Spontaneous calcium changes in striatal cells.
Electronics and Communications in Japan 94(7): 43-52, 2011. [Wiley]

Sato K, Sakamoto H, Goto M, Osanai M, Machida Y, Mori I.
A Method of CT Simulation for Users by Using Projection Data Processing.
Bull. Sch. Health Sci. Tohoku Univ. 20: 91-102, 2011. [TOUR]

Goto M, Sato K, Minakuchi S, Miura T, Osanai M, Machida Y, Mori I.
Noise analysis of CT image: improvement in low-frequency area.
Bull. Sch. Health Sci. Tohoku Univ. 20: 55-61, 2011. [TOUR]

Tamura A, Yagi T, Osanai M.
Recording of the neural activity induced by the electrical subthalamic stimulation using Ca2+ imaging.
IEEJ Trans. EIS 131: 42-49, 2011. [J-STAGE]

Osanai M, Tanaka S, Takeno Y, Takimoto S, Yagi T.
Spatiotemporal Properties of the Action Potential Propagation in the Mouse Visual Cortical Slice Analyzed by Calcium Imaging.
PLoS ONE 5: e13738, 2010. doi:10.1371/journal.pone.0013738

Miura T, Minakuti S, Kato M, Goto M, Chiba S, Kimura T, Sato K, Osanai M, Machida Y, Mori I.
SSP Measurement of MDCT : The Flaw of Slant Wire Method and Improvement by Cross Wire Method.
Bull. Sch. Health Sci. Tohoku Univ. 19: 95-106, 2010. [TOUR]

Chimoto Y, Nakata E, Komamura K, Nagasawa Y, Watanabe S, Saito H, Mori I, Tamura H, Machida Y, Ishibashi T, Chida K, Shidahara M, Osanai M, et al.
The Combination of S-1 and Oxaliplatin Enhance the Antitumor Activity in vivo and in vitro in a Human Ovarian Cancer Model.
Bull. Sch. Health Sci. Tohoku Univ. 19: 107-115, 2010. [TOUR]

Takane Y, Sato A, Fujiwara R, Mishina M, Odagiri H, Nanbu T, Kodama H, Abe Y, Yanagawa I, Ishibashi T, Takai Y, Saitou H, Mori I, Tamura G, Mahcida Y, Chida K, Osanai M, et al. 
A phantom study of comparison of cardiac SPECT analysis.
Bull. Sch. Health Sci. Tohoku Univ. 18: 83-92, 2009. [TOUR]

Ishiki T, Tanaka S, Osanai M, Doi S, Kumagai S, Yagi T.
Bifurcation-Based Model Construction of a Pyramidal Cell of the Primary Visual Cortex.
Int. J. Innov. Comp. Inf. Control 5: 831-845, 2009. [IJICIC]

Ishiki T, Tanaka S, Osanai M, Doi S, Kumagai S, Yagi T.
Global bifurcation analysis of a pyramidal cell model of the primary visual cortex: towards a construction of physiologically plausible model.
Lecture Notes in Computer Science 4984: 7-17, 2008. [Springer]

Osanai M, Yaguchi Y, Yamada N, Oboshi F, Yagi T. 
Spontaneous calcium changes in striatal cells.
IEEJ Trans. EIS 128: 1050-1057, 2008. [J-STAGE]

Osanai M, Sakaehara H, Sawai H, Song W-J, Yagi T. 
Optical recording of retinal and visual cortical responses evoked by electrical stimulation on the retina.
IEEJ Trans. EIS 127 (10): 1595-1602, 2007. [J-STAGE]

Osanai M, Kitagawa T, Yagi T. 
Evaluation of effects of electrical stimulation on the retinal ganglion cells for the retinal prosthesis.
Trans. Jpn. Soc. Med. Biol. Eng. 45 (1): 63-69, 2007. 

Osanai M, Yamada N, Yagi T. 
Long lasting spontaneous calcium transients in the striatal cells.
Neurosci. Lett. 402: 81-85, 2006. [PubMed]

Osanai M, Saegusa H, Kazuno A, Nagayama S, Hu Q, Zong S, Murakoshi T, Tanabe T.
Altered cerebellar function in mice lacking CaV2.3 Ca2+ channel.
Biochem. Biophys. Res. Commun. 344: 920-5, 2006. [PubMed]

Fang X, Sakaguchi H, Fujikado T, Osanai M, Ikuno Y, Kamei M, Ohji M, Yagi T, Tano Y.
Electrophysiological and histological studies of chronically implanted intrapapillary microelectrodes in rabbit eyes.
Graefes. Arch. Clin. Exp. Ophthalmol. 244: 364-375, 2006. [PubMed]

Fang X, Sakaguchi H, Fujikado T, Osanai M, Kanda H, Ikuno Y, Kamei M, Ohji M, Gan D, Choi J, Yagi T, Tano Y.
Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes.
Graefes. Arch. Clin. Exp. Ophthalmol. 243: 49-56, 2005. [PubMed]

Sakaguchi H, Fujikado T, Kanda H, Osanai M, Fang X, Nakauchi K, Ikuno Y, Kamei M, Ohji M, Yagi T, Tano Y.
Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes.
Jpn. J. Ophthalmol. 48: 552-557, 2004. [PubMed]

Sakaguchi H, Fujikado T, Fang X, Kanda H, Osanai M, Nakauchi K, Ikuno Y, Kamei M, Yagi T, Nishimura S, Ohji M, Yagi T, Tano Y.
Transretinal electrical stimulation with a suprachoroidal multichannel electrode in rabit eyes.
Jpn. J. Ophthalmol. 48: 256-261, 2004. [PubMed]

Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T.
CaV2.3 (α1E) Ca2+ channel participates in the control of sperm function.
FEBS Lett. 516: 229-233, 2002. [PubMed]

Toriyama H, Wang L, Saegusa H, Zong S, Osanai M, Murakoshi T, Noda T, Ohno K, Tanabe T.
Role of CaV2.3 (α1E) Ca2+ channel in ischemic neuronal injury.
Neuroreport 13: 261-265, 2002. [PubMed]

Suzuki S, Osanai M, Mitsumoto N, Akita T, Narita K, Kijima H, Kuba K.
Ca2+-dependent Ca2+ clearance via mitochondrial uptake and plasmalemmal extrusion in frog motor nerve terminals.
J. Neurophysiol. 87: 1816-1823, 2002. [PubMed]

Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T.
Analysis of Ca2+ currents in spermatocytes from mice lacking CaV2.3 (α1E) Ca2+ channel.
Biochem. Biophys. Res. Commun. 288: 1032-1036, 2001. [PubMed]

Suzuki S, Osanai M, Murase M, Suzuki N, Ito K, Shirasaki T, Narita K, Ohnuma K, Kuba K, Kijima H.
Ca2+ dynamics at the frog motor nerve terminal.
Pflügers Arch. 440: 351-365, 2000. [PubMed]

Saegusa H, Kurihara T, Zong S, Minowa O, Kazuno A, Han W, Matsuda Y, Yamanaka H, Osanai M, Noda T, Tanabe T.
Altered pain responses in mice lacking a1E subunit of the voltage-dependent Ca2+ channel.
Proc. Natl. Acad. Sci. U S A 97: 6132-6137, 2000. [PubMed]

Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T.
Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function.
J. Biol. Chem. 275: 10893-10898, 2000. [PubMed]

Narita K, Akita T, Osanai M, Shirasaki T, Kijima H, Kuba K.
A Ca2+-induced Ca2+ release mechanism involved in asynchronous exocytosis at frog motor nerve terminals.
J. Gen. Physiol. 112: 593-609, 1998. [PubMed]

Osanai M, Tsuji A, Suzuki N, Kijima H.
Presynaptic effects of a trinitrobenzene analogue at the frog neuromuscular junction.
J. Neurophysiol. 76: 1735-1743, 1996. [PubMed]
return to publication index


[Book chapters]
Osanai M.
Bio-imaging.
"Rinsyo ikougaku skill-up kouza" (in Japanese) (Haruna M, Yagi T, Tanaka M, Akashi M, Kurachi Y, Eds.), pp 81-102. Osaka University Press, 2010.

Osanai M, Takada M, Fujiwara T, Akagawa K, Yamaguchi K.
Analysis of the regulatory mechanisms of synaptic exocytosis using an autapse of cultured rat hippocampal neuron.
Neural Development (Uyemura K, Kawamura K, Yazaki T, Eds.), pp 481-485. Springer-Verlag Tokyo, 1999.
return to publication index


[Reviews]
Osanai M.
Optical imaging of the calcium dynamics in neuronal circuits.
Bull. Sch. Health Sci. Tohoku Univ. 19: 1-12, 2010. [TOUR]

Tano Y et al.
Towards clinical application of a visual prosthesis.
Nippon Ganka Gakkai Zasshi 113: 315-343, 2009.

Osanai M, Tanabe T.
Molecular pharmacology of voltage-dependent calcium channels.
Clinical Calcium 10(3): 116-122, 2000.

Osanai M, Suzuki S, Suzuki N, Kijima H, Kuba K.
Visualization and time course measurement of [Ca2+]i in the presynaptic nerve terminal.
Biophysics (Tokyo) 37: 223-224, 1997.

Osanai M, Narita K, Suzuki N, Kijima H, Kuba K.
Ca2+ dynamics and transmitter release at the presynaptic nerve terminal.
Cell Technology 16(1): 40-47, 1997.