Anti-infectives  (Track)

NEPHROPROTECTIVE EFFECTS OF SOME ESSENTIAL OILS AGAINST NANOBACTERIA INDUCED INFECTION IN MICE

K.Abo-EL-Sooud^1*, M.M.Hashem¹, Mona M.E.Eleiwa², A.Q.Gab-Allaha³

¹Dept. of Pharmacology, Faculty of Veterinary Medicine,Cairo University,Giza 12211 EGYPT
                       ²Dept. of Botany, Faculty of Science,Cairo University,EGYPT
                       ³The Holding Company for Biological Products & Vaccines VACSERA,EGYPT

Abstract

The purpose of this study was to evaluate the nephroprotective effects of nine essential oils against nanobacteria-isolated fromhuman kidney stones in Swiss mice. We found evidenceof their inflammatory infiltration and accumulation in the renal tubules indicating that the kidney is a preferred site for mineralization by nanobacteria. Among all tested essential oils, dill, almond, cinnamon, sesame and olive were found to possess highly nephro-protective effect against nanobacteria-induced infection in mice. They prevented the nanobacterial-nephro-toxicity as evidenced by a significantly reduced (p ≤ 0.01) level of serumurea and creatinine.Moreover, the nephroprotective effects of the prior oils were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings.

Although, rocket, mint, clove and lettuce oils had no renal protective effect as the biochemical and pathological findings were significantly altered. The oils-treated sub-cultures from kidneys were negative for nanobacterial growth from dill, almond, cinnamon, sesame and olive treatments while the growth were positive for the rest of the tested oils. In conclusion, nanobacteria may be involved in the pathogenesis of nephrolithiasis and dill, almond, cinnamon, sesame and olive oils have a protective role against nanobacteria-induced nephrotoxicity in mice.

Keywords : Nanobacteria; Essential oils; Kidneys; Urolithiasis.