The 1st International Conference on Drug Design & Discovery: Dubai, February 3 - 6, 2008

Abstracts of the 1st International Conference On Drug Design & Discovery

Abstract Key:
Nobel Abstracts Plenary Abstracts Invited Abstracts Session Abstracts Poster Abstracts

Note: Please click the title to view the abstracts

Nobel Abstracts

Name of Speaker Title
M. Veltman Elementary Particles and Cosmology
K. von Klitzing Physics and Applications of the Nobel Prize in Physics 1985
J. Cronin Investigations of the Origins and Nature of Highest Energy Cosmic Rays
Z. Alferov Short History of the Semiconductor Heterostructure Research
J.R. Schrieffer Spin Charge Separation in Conjugated Polymers
K. Wuthrich My Way from Sports Instructor to Research Scientist
H. Kroto Science, Society and Sustainability
Y.T. Lee Dynamics of Chemical Reactions and Photochemical Processesy
J.R. Warren Discovering Helicobacter
R. Huber Fc-receptors: Basic science and drug design
J. Deisenhofer Adventures in Structural Biology
R.R. Ernst My Pathway into Science and Beyond
K. Wuthrich Structural Biology and Structural Genomics in Drug Discovery


Plenary Abstracts

Name of Speaker Title
M. Abou-Gharbia Discovery of Innovative Therapeutics: The Pharma Perspective
S.T. Furlong The Challenges of Implementing Biomarkers in Clinical Trials
Atta-ur-Rahman FRS Some Adventures in Chemistry and Education
E. De Clercq Current Drugs for the Treatment of HIV Infection (AIDS) Role of Acyclic Nucleoside Phosphonates
K. Izuhara Inflammation and Allergy Drug Design and Discovery: Search for Novel Drug Targets for Bronchial Asthma by Microarray Approach
A. Reitz BACE Inhibitors for the Treatment of Alzheimer’s Disease


Invited Abstracts

Name of Speaker Title
S. Edmondson Discovery of JANUVIA™ (Sitagliptin): A Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
J. Maibaum Structure-based Discovery of Aliskiren - A Direct Renin Inhibitor for Hypertension Therapy
B. M. Dunn The Structural and Biochemical Properties of Non-B Subtype HIV-1 Proteases and Drug Resistance
H. Kurumizaka Structural and Biochemical Studies of Homologous Recombination toward Drug Design and Discovery
C.R. Cantor Pharmacogenetics Using an Automated Mass Spectrometry Platform for DNA Analysis
K. Fujita Pharmacogenomics in Drug-Metabolizing Enzymes: For Personalized Cancer Chemotherapy
P. Nielsen Towards Novel Gene Targeted Drugs. Progress in dsDNA Recognition and Cellular Delivery of Peptide Nucleic Acid (PNA)
L. Corcoran Functional Characterisation of New Immunomodulatory Compounds
T. Mansour Antibiotics from Natural Products: Discovery of Tygacil®
D.A. Burnett The Discovery of Cholesterol Absorption Inhibitors: From ACAT to Zetia
N. Oku Cancer Antineovascular Therapy by use of Angiogenic Vessel-targeted Liposomal Drugs
J. Kardos Glial Glutamate and GABA Transporters as Neuroprotective Targets
A. Maggi Reporter mice and Drug Discovery and Development
F. Maina HIT MetASTASIS: Unbalancing Met Activity and its Downstream Survival Signals for new Anticancer Therapies
J. Zheng Structure-based Investigation of Wnt Signaling Inhibitors
E. Pai From Enzyme Mechanism Studies to the Generation of Lead Compounds against Malaria
H.J. Guchelaar A Clinical Pharmacogenetic Model to Predict the Efficacy of Methotrexate Monotherapy in Recent-Onset Rheumatoid Arthritis
M.S. Lee The Effects of Genes Related to the Monoaminergic Pathway on the Action of Antidepressants
T. Ouchi Translational Approach to Study Anti-Cancer Drugs Using Mouse Model of Breast Cancer
J. St-Amand High Throughput Functional Genomics Strategy to Discover New Therapeutic Targets for Complex Diseases
I. Toth Vaccine Delivery: Synthesis and Investigation of a Highly Pure, Multi-Epitopic Lipopeptide Vaccine Candidate
O. Alpar New delivery challenges: Nanocarriers for the Delivery of siRNA
P. Artursson Profiling and Prediction of Drug Transporter Interactions
A. Bernkop-Schnuerch Multifunctional Polymeric Excipients: The Key for Oral Delivery of Peptides and Nucleic Acids?
D. Craik Cyclotides as a Peptide-Based Combinatorial Template for Drug Design
T. Rades Nanoparticles As Delivery Systems For Subunit Vaccines - A Pharmaceutical Approach
M. Roberts Targeted Topical Drug Delivery
R. Dolle Single-Step N-Heterocyclic Annulation Reactions for High Throughput Chemistry
S. van Calenbergh Synthesis of Fosmidomycin Analogues: Towards Potent Antimalarials
T.M.S. Chang Novel Nanomedicine Based Therapeutics
A. Cherkasov Cheminformatics Delivers Super-antibiotics for Superbugs
B. Fowler
Development and Validation of Emerging “Omic” Biomarkers for New Drugs: An Overview of Lessons Learned from High Technology Materials
T. Hogberg Novel Design Principles fro GPCR Specific Libraries
G. Bertho The Expanding Role of NMR in the Early Steps of Drug Design and Discovery
J.R. Hwu New Bionano Materials for Drug Delivery
I. Ojima Design, Application, and Chemical Biology of Tumor-Targeting Drug Conjugates
C. Prakash Strategies for the Selection of Drug Candidates for Development: An Overview
E. Arinc Cytochrome P450 Dependent Drug Metabolism and Outcomes of Drug-Drug Drug-Toxicant Interactions in Diabetes
K. Beaumont Mitigating the Reactivity of Acyl Glucuronides in a NEPi Discovery Programme
A. Kalgutkar The Role of Drug Metabolism and Drug Transport in Idiosyncratic Adverse Drug Reactions
W. Banks Transport of Antisense across the Blood-Brain Barrier
M.I. Choudhary Nature - Source of New Pharmacophores
G. Whitlock Serotonin/Noradrenaline Reuptake Inhibitors: A Case History in the Challenges of CNS Drug Discovery
A. Kozikowski Histone Deacetylase Inhibitors, Neuroprotection, and CNS Disorders
J.M. Brunel Stereoselective Synthesis of Squalamine Analogues: Evaluation of their Antimicrobial Activities
K. Hostetler Alkoxyalkyl Acyclic Nucleoside Phosphonates for Smallpox and other Viral Diseases
M. Preobrazhenskaya Chemistry and Biology of Glycopeptide Antibiotics
S. Nwaka Global Networks for Drug Discovery for Infectious Tropical Diseases
Y. Al-Abed Identification of MIF’s Proinflammatory Site: A Novel Target for Drug Discovery in Autoimmune and Inflammatory Diseases
O. El-Agnaf A Strategy for Designing and Screening Inhibitors of α -Synuclein Aggregation and Toxicity: As a Novel Treatment for Parkinson's Disease
F. Nyberg The Substance P System as a Target in the development of Peptidomimetics acting as Potential Pain Relievers and as Drugs for Treatment of Opiod Addiction
H. Renz Development of new Therapeutic approaches in Allergy and Lung Disease: The Antisense Strategies
X. Wehrens Intracellular Calcium Release Channels - Promising Targets for the Treatment of Heart Failure And Arrhythmias
G. Brooks Targeting the Cell Cycle Machinery for Cardiac Regeneration
J. Gibbins Innovations in the Development of Anti-Platelet Therapies for the Prevention of Thrombosis
K. Hasegawa A Pharmacological Heart Failure Therapy that Targets Nuclear Pathway in Cardiac Myocytes
M. Waring The Long March towards Effective and Selective Drug Treatment of Cancer
P. Herdewijn Chemical Modified Sirna for the Inhibition of P-Glycoprotein Expression
S. Ingvarsson Genomic Instability in Breast Cancer
A. McCluskey Advanced Lead Development - Just How Complex Does if Need to be
B. Pirotte The Use of SUR1/Kir6.2-Selective Potassium Channel Openers in the Treatment of Endocrine Metabolic Disorders Associated with Hyperinsulinemia : Recent Developments and Future Prospects
L. Prokai Brain-Selective Estrogen Therapy
M. Sinz Predicting Enzyme Induction and Drug-Drug Interactions
R. Weaver Challenging R&D Paradigms by Use of Microdose and Microtracer Studies During Non-Clinical Development and Beyond
M. Barton Novel Aspects of Estrogen Receptor Signaling for Vascular Disease and Therapy
H. Kasuya Future Development of Oncolytic Virus Therapy
A.J. Melendez Sphingosine Kinases Emerging Therapeutic Targets in Inflammation and Allergy
E. Prossnitz GPR30 as a Novel Biomarker and Drug Target
J. Jimeno The Development of Marine Derived Anticancer Agents in the Era of Targeted Therapies
L. Khachigian Targeting Key Transcription Factors in Various Experimental Cardiovascular Pathologies
M. Searcey Targeting the Holliday junction: A New Target for Cancer Research?
K. Geckeler Supramolecular Anticancer Drugs: From Design to Reality
H. Lashuel Protein Misfolding and Fibrillogenesis in Neurodgenerative Diseases: From Mechanistic Studies to Therapeutic Strategies
C. McCurdy Sigma Receptor Ligands as Pharmacotherapy for Psychostimulant Abuse
E. Marechal Screening for Drugs with Herbicidal, Algicidal and Antiparasitic properties: a novel Paradigm to Discover new Antimalarial Compounds
A. Mjalli The Use of TTP Translational Technology to Discover Novel Treatments for Alzheimer's Disease, Cardiovascular Diseases & Diabetes
T. Ruckle PI3Kγ and PI3Kδ Partners in Crime in Inflammation? Rheumatoid Arthritis and Beyond
K. Tsuji Differential Production of Connective Tissue-Type and Mucosal Mast Cells from Human Embryonic Stem Cells for Anti-Allergy Drug Screening
R. Wallis Assessing the Infection Risks of New Anti-Inflammatory Therapies
T. Takahashi Prevention of Cardiovascular Diseases by Regulation of Endothelial Cell-Neutrophil-Cytokine Interaction
I. Shcherbakova How to Learn Lessons from Failures: Discovery and Development of Novel Neuronal L-Type Calcium Channel Blockers
G. Semple Discovery of MK-0354: a Niacin Receptor Partial Agonist with Acute Antilipolytic Activity but Little Flushing Effect in Preclinical Species and in Humans
M. P. Costi Interfering with Human Thymidylate Synthase Dimerization: a Strategy for Folate pathway down Regulation in Platinum Resistant ovarian Carcinoma
S. Tkachenko Discovery and Development of Orally Bioavailable 5-HT6 Receptor Antagonists for Cognition Enhancement in Treating Alzheimer’s Disease. Fingerprinting Approach to Clinical Candidates. Parallel Optimization in “Constellation” of CNS Targets
K. Strebhardt Perspectives of Novel ATP- and Non-ATP-Competitive Kinase Inhibitors: Targeting Polo-Like Kinase 1 for Anticancer Therapy
A. Haoudi A New Era of Medicine “Genomic Medicine”: Connecting Genes, Drugs and Diseases
X. Morelli From Virtual Screening to Experimental data: A Foursome to Inhibit Protein-Protein Interaction involving nef from HIV
L. Ghosez Synthesis: A Creative Engine for Drug Discovery and Development
H.H. Fiebig Gene Signatures Predicting Tumor Response to Cytotoxic Drugs
H. Cheradame Can the Block Copolymers Hurdle the Whole Process of DNA Transfer?
A. Ashkar Targeting the innate immune system to fight infection
R.M. Fusaro The Maillard Reaction for Melanoidins-Sunscreen Formation: New Technical Standards Needed to Evaluate Effectiveness
Y. Wang Developing Novel Anti-inflammatory Therapy for Asthma/COPD
C. Freund Proline-Rich Sequence Recognition: Principles and Molecular Interference
M. Suzuki An Efficient, General Synthesis of 11C- and 18F-incorporated PET Tracers Toward Revolutionizing Drug Development and Diagnosis
B. Zacharie Triazine Derivatives as Protein A Mimetics for the Treatment of Autoimmune Disease


Session Abstracts

Name of Speaker Title
P. Boulikas Tumor-Targeted Liposomal Cisplatin (Lipoplatin™) and Oxaliplatin (Lipoxal™) show Superiority to Free Drugs: from Inception to Phase III
G. Campiani Development of Potent Atypical Antipsychotics based on A Novel Neurochemical Approach
P. Talaga Frontiers in Medicinal Chemistry. Time for another Big Bang?
N. Pugno Smart Flexible Nanovectors
G. Osuji Discovery of the RNA Synthetic Activity of Glutamate Dehydrogenase and Application in Drug Metabolism
A.D.N. Vaz Aldehyde Oxidase in Drug Metabolism: Simple Preclinical Tests to Avoid Potential for Clinical Pharmacokinetic Failure
A. Milosavljevic A Comprehensive Map of Chromosomal Aberrations in the MCF-7 Breast Cancer Cell Line Genome: Technology, Informatics, and Significance
F.M. Veronese Therapeutic Proteins: New Achievements for Stabilization and Delivery
B. Roca (Villanueva) Pharmacogenomics of Antiretrovirals
D. Grainger
Title Awaited
P.G.M. Rao Adverse Drug Reactions among Hospitalized Patients in Nephrology Wards-An Intensive Monitoring Study
K. Yasuda
Title Awaited
K.K.W. Wang New Theranostic Approach to Diagnose and Treat Traumatic Brain Injury
R. Minchin Multi-Component Peptide-Based Carriers for Non-Viral DNA Delivery
F. Darvas Enabling Novel Technologies to Expedite Medicinal Chemistry: Combination of Flow Synthesis and Serendipity-Enhancing Technics for Lead D iscovery
Y. Perrie Delivering DNA and Protein Antigens – A Role For Cationic Liposomes
P. Simerska Vaccines against group A Streptococcal Infection and Human Papillomavirus Type-16 associated Cervical Cancer
M. Stenzel Crosslinked Micelles via the Raft Process: Towards a more Biocompatible Gene Delivery System
E. Gordon Integrating Gene-Brain-Behaviour Markers for the era of ‘Personalized Medicine’
E. Kmonickova Nitric Oxide as a Biomarker of Immunostimulatory Activity of Drugs
Y. Korpan Cancer Diagnostic and Prognostic: European Research Strategies, Recent Sensor Achievements and New Targets
R. McDade Following the Critical Path: Development of Multi-Analyte Profiles for Sensitive, Early Detection of Toxicity
S. Mukaddam-Daher Cardiac Imidazoline Receptors, a New Therapeutic Target
K.S.A. Khabar Molecular Response to Therapeutic Interferons: Sensitivity and Resistance Mechanisms
M. Yoshioka Identification and Characterization of Therapeutic Targets for Prostate Cancer
B. Rochat Role and Importance of Hepatic and Extrahepatic Drug Metabolizing Enzymes in the Bioavailability of Anti-Cancer Agents in Cancer Cells
V. Apostolopoulos Peptide based Vaccines: A Structural and Immunological Perspective
U. Bachrach Imino-aldehydes- a new tool to Combat Cancer and Viral Diseases
U. Baltayev Antiulcer and Cardiovascular Compounds(steroids): Structure Activity
A.J. Mendonca Novel Building Blocks and Templates for GPCR and Kinase Research
C. Maercker Inducible Nidogen Expression in Epidermal HACAT Cells
J. Nielsen Synthesis of Bioactive Natural Products
V. Sakanyan Development of Small Molecule and Antibody Microarrays Designed for Drug Discovery
In-C. Kang High-Performance Screening of Active Peptide Inhibitor of Integrin Receptor by Protein Microarray Chip
J. Tavernier The MAPPIT Toolbox: Strategies to Analyze Molecular Interactions in Intact Cells
A. Yuryev In Silico Pathway Analysis: The Final Frontier Towards Completely Rational Drug Design
S. Hannongbva
Title Awaited
J. Turnbull “Engineered Heparins”: Novel Beta-Secretase Inhibitors as Potential Therapeutics for Alzheimer's Disease
B. Potter Steroid Sulfatase Inhibitors: From Concept to Clinic
A. Tsarbopoulos
Title Awaited
S. Krol
Title Awaited
M.S. Shekhani Using Sugars in Drug Discovery
E. Carrier Artificial Hematopoietic Stem Cell Niche Sustains Growth and Differentiation of Human ES-Dervied Early Hematopoietic Pregenitors
Y. Kitade Synthesis of 2', 5' -Oligoadenylates Having Aromatic Groups and their Biological Activities
S. Dastmalchi Prediction of Structural Features of Integral Membrane Proteins
I.A. Bashir The use of gum arabic fraction for treatment of chronic renal failure patients
A. Khalid From Molecular Recognition to Drug Design:Applications of Experimental and Theoretical Enzyme Inhibition Studies
K. Fox Towards the Targeted Modulation of Gene Expression by Modified Triplex-Forming Oligonucleotides
K. Suzuki Protein C Inhibitor Regulates Breast Cancer Cell Growth, Metastasis and Angiogenesis
F. Vallette Apoptosis as a Target for Peptide and Protein Therapies
A. Al-aboudi Cholinesterases Inhibitory Activity of Testosterone and Some of its Metabolites
M.A. Eldaway Design Studies of Drugs for the Management of Certain
Parasitic and Hepatic Viral Infections
C.W. Huck
Title Awaited
B. Coulombe Inhibitors of Multisubunit RNA Polymerases as Tools to Study Transcriptional Mechanisms in Prokaryotes and Eukaryotes
A.H. Al-Marzouqi Effect of Preparation Method on Physicochemical Properties of Antifungal Drug-Cyclodextrin Complexes - Comparison between Supercritical Carbon Dioxide and Conventional Methods
C. Berthelette Case Study of DP Receptor Antagonists: From HTS to Synthesis and Selection of Pre-Clinical Candidate Compounds
J. Bandow Identification and Characterization of Novel Antibiotic Targets
C.-H. Lai The Asian Gynecologic Oncology Group and Clinical Trial Center of Chang Gung Memorial Hospital
H. Gardsvoll Mapping Structural and Functional Epitopes for Ligand and Monoclonal Antibody Binding on the Receptor for Urokinase-Type Plasminogen Activator: Identification of Potential Target Sites for Antagonist-Based Cancer Therapy
V. Gault GIP-Based Therapeutics for Diabetes and Obesity
A. Kamel The Role of Aldehyde Oxidase in the Metabolism of the Antipsychotic Drug Geodon
H. Hassan Regioselective Synthesis of Symmetric Pyridine-Spaced Sulfated Glucuronic Acid and Study of Their Antiproliferative Activity
A. Martinez From Rational Drug Design To Disease Modifying Drugs For Alzheimer´s Disease
J. Chin-Dusting The Heterogeneity of High Density Lipoproteins: Implications for Therapeutic Development.
C.-H. Chen New Drug Development following Characterization of a Novel Atherogenic Lipoprotein
C. Szabo Development of Gaseotransmitters (Nitric Oxide, Carbon Monoxide, Hydrogen Sulfide) as Pharmaceutical Agents: Past Challenges, Future Opportunities
K. Ogata Regulatory Mechanism of Assembly of Transcription Factors on DNA
G. Kleymann Discovery of New Drugs and Innovative Therapeutic Principles for Superior Treatment of Herpes Disease
P. Yu Vascular Surface Semicarbazide-Sensitive Amine Oxidase (SSAO/VAP-1) as a Novel Target for Treatment of Chronic Vascular Disorders Associated with Protein Misfolding and Inflammation
R. Alany Corneal Delivery and Stability of Connexin 43 Antisense Oligonucleotides
S. Al-Assaf Controlling the Physicochemical Properties of Polysaccharides and Proteins
J. Blanchfield The Development of Polymer Based Synthetic Vaccines
J. Du Plessis Transdermal Delivery of Arginine Vasopressin with Pheroid™ Technology
R. Falconer Selective Delivery of Anti-Tumour Agents via Matrix Metalloproteinase (MMP)-Cleavable Peptides
M. Foldvari Prospects for Non-Invasive Delivery of Proteins and Nucleic Acids Across the Skin
S. Celikoglu A New Paradigm for Cancer Chemotherapy: Intratumoral Drug Delivery
M. Kuzuya A Novel Drug Engineering by Plasma Technique
R. Pasqualini/W. Arap Ligand-Directed Therapy and Molecular Imaging based on In Vivo Phage Display Technology
K. Pankiewicz NAD-based Anticancer Therapeutics
M.A. Abdullah Cell Engineering and Molecular Pharming for Biopharmaceuticals
M. Walter High Throughput X-ray Crystallography: Feeding the Drug Discovery Pipeline
Z. Witczak Thio-sugars as Emerging Targets for Carbohydrate Therapeutics Discovery
T. Al Tel Diversity-Oriented Synthesis: Enantioselective Synthesis of a Pool of Small Molecules as Drug Candidates
A. Peracchi How (and why) to revive a dead enzyme: the power of chemical rescue
N. Zgheib The Effect of Liver Disease on Cytochrome P450 Mediated Metabolism
V. Brabec Platinum Coordination Complexes. from DNA Interactions to New Anti-Tumor Drug Design
I. Gockel Novel Therapeutic Targets in Esophageal Cancer: Impact of Coexpression of Receptor-Tyrosine-Kinases (RTK) and Chemokine Receptor CXCR4
R. Kiss The Sodium Pump and Its Alpha1 and Alpha3 Subunits as Novel Targets to Combat Apoptosis- and/or Multidrug-Resistant Proliferating and Migrating Cancer Cells
V. Djonov
Title Awaited
A. Pertis Non-Natural Nucleotide Analogs as Probes of DNA Polymerase Activity
A. Ali Discovery of Novel, Selective Glucocorticoid Receptor Modulators
R. Assaly Plasma Expansion by Polyethylene Glycol Modified Albumin (PEG-Alb)
L. Chugh Dengue Virus Viremia: Role of NS1 Protein of Virus / Cytotoxic Factor Produced by T-Cells
J. De Sanctis New Glutarimide Alkaloids as Potent Anti-Inflammatory Drugs
C.D. Ribas Relevant Effects of Omalizumab, an Anti-Ige Drug, In Asthma and other Diseases
P. Sayeski Jak2 and Reactive Oxygen Species: A Complex Relationship
G. Leclercq Implication of Estrogen Receptor α in Breast Cancer Development - A New Concept for the Development of Drugs Aimed to Antagonize its Action
C.-T. Lin Peptide-Targeted Chemotherapy against Nasopharyngeal Carcinoma
S. Linder A Biomarker Concept for Anticancer Drug Development
N. Eikje Identification and Characterization of Skin Biomolecules for Drug Targeting by Vibrational Spectroscopy
Y.-C. Kuo The Immunomodulatory Activities of (S)-Armepavine on Autoimmune Diseases In vivo and In vitro
W. Chegwidden The Carbonic Anhydrases: Potential Therapeutic Targets in Renal Carcinoma
G.B. Fields Mechanism and Inhibition of Collagenolytic Matrix Metalloproteinases
S. Qureshi Improved In vitro Model to Assess Drugs Release Characteristics of Products for their Absorption from Human Gastrointestinal Tract
B. Imbimbo The Therapeutic Potential of γ -Secretase Modulators in Treating Alzheimer’s disease
M. Botta The Fight against AIDS: New Avenues for Inhibiting RT, an Old Target
T. Prisinzano Discovery of mu Opioids with altered Receptor Regulation
N. Zawia A Novel class of Mechanism-based Drugs for the Treatment of Alzheimer’s Disease
U. Holzgrabe Piggy Back Approach: Bisaphthalimides As Muscarinic Agnoists, Cancerostatics, And Antiinfectives
R. James Developing Novel Antimicrobial Peptides Active Against Gram-Positive Pathogens
L. Polonelli Engineered Antibody Cdrs As Novel Antimicrobial, Antiviral And Antitumor Drugs
C. Salmi Squalamine, A New Antibiotic Extracted From Marine Environment: How about Its Mechanism Of Action With Respect to Gram-Negative Bacteria?
M. Alam High Throughput Compound Library Screening for Potential Antiviral Drugs for Dengue Virus
K.-I. Sato Focused Proteomics on Membrane Microdomain-associated Signal Transduction in Fertilized Amphibian Eggs and Human Bladder Carcinoma Cells
P. Aljama Optimizing the Use of Erythropoiesis Agents (ESA) in Renal Anemia
A. Pini Identification, Optimization and In vivo Activity of a Branched Antimicrobial Peptide Selective For Gram-Negative Bacteria
H.-M. Chen Structure of a Novel Anticancer Peptide CB1a, Based on the N-terminal Peptide Sequence of Cecropin B
L.-K. Chau Rapid and Label-Free Bio-Detection Based on Localized Plasmon Resonance
D. Steinbach Which ABC-transporters should we target in Leukemia?
E. Terpos Proteasome Inhibition Therapies and Bone Metabolism in Multiple Myeloma
M. Turkay Identification of Drug Candidates for Prostate Cancer Using Computational and Experimental Methods
S. Shigeta Anti-RNA Virus Activity of Polyoxometalates
D. Buchi Immune System Modulation with a Homeopathic Medication.
W. Childers Serotonergic Drug Design - Finding Diamonds in the Rough
Y. Collette HIV-1 nef-SH3 Targeting as a Proof of Concept for the Development of Anti-Viral Protein-Protein Interaction Inhibitors
E. Elzein Discovery of CVT-6883: A Novel A2B Adenosine Receptor Antagonist as a Clinical Candidate for the Treatment of Asthma
A. Grobler Pheroid TM Technology: A Novel Drug Delivery System with Broad Application
B.Noszal Molecular Mechanism of Morphine-6-Glucuronidate Brain Penetration
J.O.V. Planells Transcorneal Permeation of Nsaids Drug Delivery in a Corneal Device
S.E. Mansour Synthesis and Antimicrobial Activity of some Novel Oxadiazole Derivatives
A. Damas TTR Amyloidosis: from the Molecular Mechanism to Therapy
K. Filipiak How can we Prevent Diabetes in Pharmacological way ?
H. Kang Peroxisome Proliferator-Activated Receptor Delta Selective Agonists as Potent Anti-Atherogenic Agents In vivo
J. Zablocki Novel Aldehyde Dehydrogenase-2 Inhibitors as a Potential Treatment of Alcohol Addiction
C. Assaf Emerging Drugs in Cutaneous Lymphomas
S. Kumar Can the Acute Toxicity of Antidepressants be Predicted Using the Protozoan Tetrahymena pyriformis?
D. Dizon From Bench to Bedside: The clinical development of pertuzumab in women's cancers
M. Gyongyossy-Issa A synthetic platelet as application of a targeted controlled-rate drug delivery vehicle
H.-G. Ljunggren Prospects for the Use of NK-Cells in Immunotherapy Against Human Cancer
G.-J. Wang Endotoxin-Stimulated Responses and Therapeutic Herbal Medicines Development by a Systems Biology Approach
M.J. Drysdale Structure Based Discovery of Hsp90 Inhibitors for the Treatment of Cancer
B. Ahmed Antihypertensive, Cardiovascular and β-Blocking Adrenergic Activity of Aryloxypropanolamines
A. El-Dahshan An Efficient Solid Phase Synthesis Concept for the Preparation of various Novel Biologically Active Peptide Mimetics
E. Goldsmith Unique Autoinhibitory Dimers in the MAP2K MEK6, and MAP4K OSR1
R. Scott
Title awaited
M. Shamssain Novel Strategies for the Treatment of Asthma and COPD - Future Challenges of Drug Therapy
H.H.A.-M. Hassan Regioselective Synthesis of Symmetric Pyridine-Spaced Sulfated Glucuronic Acid and Study of their Antiproliferative Activity
R. Howes Development of Inhibitors of Hsp90 for Cancer Therapy: The Screening Story


Poster Abstracts

Name of Presenter Title
E. Afrasiabi Anticancerous Properties of Phorbol 12-Myristate 13-Acetate (PMA) in Human Thyroid Cancer Cells
Z. Zaheer Stability indicating HPTLC Determination of-Carvedilol in Pharmaceutical Dosage Form
P. Alexandrino Fernandes Computational Mapping of Druggable Sites in Proteins
M. Abdouss Uniformly Sized, Molecularly Imprinted Polymers for Enantioselectivity of Pseudoephedrine by Precipitation Polymerization
P. Andrade HPLC-DAD-MS/MS-ESI Screening of Phenolics with Potential Bioactivity in Pieris Brassicae L. Reared on Brassica Rapa Var Rapa L.
M. Alam High Throughput Compound Library Screening and Herbal Supplements to Mitigate Dengue Fever
N.A. Atatreh Inhibition of Src for Potential Use in Cancer Chemotherapy
A.M. Aubertin Anti-HIV Prodrugs Conjugating a Reverse Transcriptase Inhibitor with Integrase Inhibitors by a Spontaneously Cleavable Linker: Synthesis and Evaluation of Antiviral Activity
M. Beiner Nanoconfinement: A strategy to manipulate the crystallization behavior of drugs
N. Belacel Intelligent Decision Support System-Based Biomarker Discovery
K. Orrling Investigation of the P1’ Substituent - Synthesis and Evaluation of Inhibitors of Malarial Aspartic Proteases.
L. Navidpour Synthesis and Anti-helicobacter Pylori Activity of (Z)-2-(nitroimidazolylmeth-
ylene)-2(3H)-Benzofuranone Derivatives
M. Asahi Discovery of a Drug that Blocks the Trojan Horse-like Strategy Used by Pathogenic Helicobacter pylori and its Associated Bacteriophage
Y.-an Bi Use of the Cryopreserved Human Hepatocyte Sandwich-Culture Model to Measure Hepatic Metabolism and Biliary Efflux
D. Bikiaris Improvement of Fluvastatin Controlled Release Through the Use of New Biocompatible Aliphatic Polyesters
L. Krivankova Elimination of Matrix Effects in Analyses of Trace Metabolites in Body Fluids by Capillary Electrophoresis
G. Horvath Synthesis, Characterization, and Biomedical Evaluation of a Novel Water-Soluble Platinum-Based Anticancer Drug
N. Bovin New Paradigm in Anti-Viral Therapy
J. Breytenbach 1. Cytarabine Prodrugs for Transdermal Delivery
2. Novel Prodrugs of Lamivudine and Zidovudine for Transdermal Delivery in the Treatment of HIV/AIDS
F. Burczynski Hepatoprotective Effect of Diltiazem and Silymarin.
F. Carrier Molecular Understanding of Histone Deacetylase Inhibitors (HDACIs) Efficiency in Cancer Cells.
L. Chalissery An Effective Purification Method for Cucurbit [N]Uril; A Molecular Host and Drug Delivery Vehicle
M. Furch Allosteric Inhibitors of Myosin Function
J. Du Plessis Transdermal Delivery of Arginine Vasopressin with Pheroid™ Technology
A. Chimirri Combined Ligand-Based and Target-Based Approach to Design NR2B/NMDA Receptor Antagonists
J. Chin A Semi-Total Synthesis of Guggulsterones, Natural Hypolipidemic Drugs, from Various Steroids
C. Soria A Novel Strategy of Anti Cancer Therapy: Targeting Specifically the Gtpase Rhoa and Development of a New Strategy for Sirna Therapy: In Vitro and In Vivo Assays
S. Christensen Peptide Inhibitors of DNA Replication in Staphylococcus Aureus
S. Achour Kinetic study on the Decomposition of 2-Chloroethylnitrososulfamides (CENS) in Organic Media
E. Valeur Dual Fragment Microarrays : Towards a New Perspective for Drug Discovery
M. Correia-da-Silva Anticoagulant Actions of Structure-Diverse Sulfated Phenols
R. Dghaim Palladium Catalyzed Multicomponent Reactions: A Facile One-Pot Coupling Approach to α-Amino Acid and Peptide Derivatives
H. Doi Pd(0)-Mediated Rapid C-Methylations for the Synthesis of 11C-Incorporated PET Tracerrs
G. Duburs Peptide-Like and Lipid-Type Compounds on the Basis of Unsaturated Cyclic Amino Acids-Carbonyldihydropyridines
H. Durchschlag Modeling of Individual Water Molecules Preferentially Bound to Proteins
D. Egan Apoptotic Cell Death and Cell Cycle Events Mediate the Action of 6-Hydroxycoumarin-3-Carboxylatosilver in Human Malignant Hepatic Cells
B. Flynn Discovery of BNC105P, A Clinical Candidate for the Treatment of Cancer: A Case Study in the Application of the Diversity-Oriented Synthesis Technology, MultiCore®
E. Fagadar-Cosma New Asymmetric meso-Tetraphenylporphyrins Peripherally Diverse Substituted with Pyridyl or Dimethoxy Groups as Promising Photosensitizers in Photodynamic Therapy
A. Siriviat Electric Field Drive Transdermal Drug Delivery of Salicylic Acid -Loaded Polyacrylamide Hydrogels
I.M. Fenyo Retinoids Induce Apoe Gene Upregulation in Macrophages
P. Kothary Greater Inhibition of Connective Tissue Growth Factor Synthesis By a MAP Kinase Inhibitor Compared to Amino Guanidine in Cultured Human Retinal Pigment Epithelial Cells
S. Gobec New Inhibitors of D-Alanine:D-Alanine Ligase (Ddlb) Discovered By Structure-Based Virtual Screening of the NCI Diversity Set
K. Goracinova Efficacy of Microparticulated Bds Dosage Forms in the Treatment of Experimentally Induced Colitis in Rats
T. Kowalska On the In Vitro Oscillatory Chiral Inversion of Selected L-Amino Acids and its Implications.
K. Shayesteh Powder Mixing and Influence of Solvent on Mixture Quality in the Production of Amlodipin Tablet
H.R. Ha Chemical Structure-Aqueous Solubility Relationship of Amiodarone
G. Hadzic Dynasore is not Dynamin Inhibitor
V. Khavinson Peptide Regulation of the Functional Activity of the Retina
E.W. Hansen A Novel Human-Cell Based Pyrogen Test
R. Akkina A New Humanized Mouse Model for Testing HIV/AIDS Therapies and Microbicides
M.Y. Yoon Overexpression of Tubulin and its Inhibitor Screening for Microtubule Formation in Phytophthora Capsici
M. Hassan Antineoplastic Effects of α-Terpineol, Linalyl Acetate and dl-Camphor, Components of Lebanese Sage Essential Oil
R. Ward Correlation of Activity and Sequence Similarity in Kinase Targets
S. Hassan Antineoplastic Effects of α-Terpineol, Linalyl Acetate and Dl-Camphor, Components of Lebanese Sage Essential Oil
K. Musilek Acetylcholinesterase Reactivator – Oxime HI-6 – Antidote Against Nerve Agents
H. Hibasami Blazein (A New Steroid) Isolated from Mushroom (Agaricus blazei Murill) Induce Apoptosis in Human Lung Cancer LU99 and Stomach Cancer KATO III Cells
T. Bruckdorfer PEGylation – A Key Technology to improve Solubility and Pharmacokinetic of Peptides, Proteins and other Biopharmaceuticals for Superior Drug Delivery
M. Steiert Nanoparticle-Based Delivery of Aminoglycoside Antibiotics
S. Imreh A Microcell Hybrid Based "Elimination Test" in Anticancer Drug Design
D. Janezic Protein-Protein Binding Sites Prediction
G.A. Spyroulias Novel Insights into Angiotensin-Converting Enzyme Domain Selectivity & Structure-Based Drug Design
K. Al-Kuraya Ubiquitin-Ligase SKP2 Pathway is an Attractive Target for Colorectal Cancer Therapy
A. Helgee A Method for Automated Molecular Optimization by Inverse QSAR Applied to Ames Mutagenicity Data
R. Kamel Polymeric Matrix System for Transdermal Delivery of Tramadol Hydrochloride
S. Kanan Detection and Identification of Banned Chemicals in Dietary Food Supplements
E. Karavas Hydrogen Bonding Interactions as a New Sustain Release Mechanism
J. Kasparkova Unique Properties of DNA Interstrand Cross-Links of Antitumor Oxaliplatin
J. Kelly Can the Acute Toxicity of Antidepressants be Predicted Using the Protozoan Tetrahymena pyriformis?
A. Sirivat Controlled Release of Sulfosalicylic Acid from Polypyrrole/Poly(acrylic acid) Hydrogel by Electrical Stimulation
J. Garmendia β2 Adrenoreceptor Polymorphism in Asthmatic Population in Venezuelan
A. Khvat Rational for Focused DiversityTM Approach to Discovery of Signaling and Developmental Pathway Inhibitors. A Case Study for PI3K and Hh Modulators
L. Carlsson Local Interpretation of Machine-Learning Models using Attribute Gradients, Applied to Ames Mutagenicity Data
P. Ohrngren Evaluation of Various P1’ Substituents in Tertiary Alcohol Containing and Elongated HIV-1 Protease Inhibitors
O. Lagerlund α-Arylation of a Protected Glycine in Water: 3-Phenylglycine Derivatives as Inhibitors of the Tuberculosis Enzyme, Glutamine Synthetase
L. Kock Aspirin: The Anti-Inflammatory Antifungal
A. Vakili Effect of central blockage of gap junction by Carbenoxolone on ischemic damage in transient model of focal cerebral ischemia
S. Komba General Strategy for Synthesis of Oligosaccharide Combinatorial Library to Develop for Oligosaccharide Array
H. Fessi Preparation and Characterization of Radioactive Dirhenium Decacarbonyl-Loaded PLLA Nanoparticles for Radionuclide Intra-Tumoral Therapy
E. Valeur Towards Potent Inhibitors of the Mdm2-P53 Protein-Protein Interaction
J.S. Kovach A New Inhibitor of Serine-Threonine Protein Phosphatase, PP2A, Suppresses
Growth and Induces Differentiation of Medulloblastoma Cells
M. Asahi Therapy against Microbial-Encoded ITAM-Like Motifs May Treat and/or Prevent a Number of Serious Infections Caused by Microbial Pathogens
M. Kukhanova Design of Depot Forms of Anti-Hiv Agents Based on Nucleoside -Phosphonate Derivatives
G. Kulcsar Preclinical Experiments on Culevit Infusion Developed on the Basis of a Passive Antitumor Defence System and Investigation of Mechanism
K.L. Lou Improvement of Drug Virtual Screen By GA/GP: Docking Studies on Tubulin Inhibitors as Anticancer Agents
B. Lammek Influence of Bulky 3, 3- Diphenylalanine Enantiomers Replacing Position 2 of Arginine Vasopressin and its Analogues on their Pharmacological Properties
E. El-Bastawiss Molecular Docking and Analysis of Certain Potent Anti-angiogenic Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Inhibitors
F. Lefranc Narciclasine Displays Potent and Selective Anti-Tumor Effects by Impairing Cancer Cell Migration Through a Phosphocofilin-Mediated Increase of Actin Stress Fibers
W. Liebenberg An In vitro Evaluation of the Efficacy of Anti-Malaria Drugs by Pheroid™ Technology
J.C. Lin Inhibitory Effects of Some Derivatives of Glycyrrhizic Acid against Epstein-Barr Virus Infection: Structure-Activity Relationships
M. Lise Effect of Moist Heat Sterilisation on Pyrogenicity of Whole Bacteria and Cell Wall Components from Staphylococcus aureus
Z. Zidek Novel Group of Biological Response Modifiers: Inhibitors of Endoplasmic Ca2+-ATPase
A.A. Taherian Comparison the effects of aqueous extract of Glycyrrhiza Glabra, Dexamethasone and stress on acute and chronic pains in mice
M. Degani Synthesis and Biological Evaluation of Novel Antifolates Towards Filariasis
Y. Zhao Cucurbit[N] Uril for Drug Delivery
A. Maghazachi The Copolymer-1 Glatiramer Acetate (Copaxone) Inhibits Natural Killer (NK) Cells Lysis of Tumor Cells but Enhances Their Cytolysis of Syngeneic or Allogeneic Immature and Mature Monocyte-Derived Dendritic Cells
R. Müller Action of Disorazol A in Combination with Other Tubulin-active Compounds
N. Belacel Theoretical Analysis of Metabolic Pathways in Cancer Development - The Effect of Zn2+ Concentration Changes on Prostate Cell Metabolism - Authored by Miroslova Cuperlovic-Culf and Nabil Belacel
B. Zhang In Silico Protein-Protein Interaction Peptide Inhibitors Design for Cyclin-Dependent Kinase5 (CDKs)
M.C.Manca de Nadra Viability Modification of Listeria Monocytogenes by the Effect of Phenolic Compounds Combination
J. Bappu A Novel Therapeutic Use of Fibrin Sealant to Promote Saphenous Graft Wound Healing in Patients Undergoing Cardiac Surgery: A Randomised Study
A. Khalid Searching for New Cholinesterases Inhibiting Drug Candidates from Natural Sources
A. Yarat Investigation of the Effect of Silymarin on the Liver in Experimental Sepsis
E. Mohamed Probing the HIV Reverse-Transcriptase Enzyme: Synthesis and Biological Evaluation of Novel Bifunctional NRTI/NNRTI HIV-1 Reverse-Transcriptase Inhibitors
A. S. Yang Molecular Modeling of Protein-Substrate Interactions in Factor-Xa with High-Throughput Substrate Phage-Display Data
M. Muñoz Neurokinin 1 Receptor Antagonist Aprepitant as an Antitumor Drug
P. Muretto Endogastric Capsule for E-Cadherin Gene (CDH1) Promoter Hypermethylation Assessment in DNA from Gastric Juice of Patients with Gastric Cancer
A. A. Vafaei Effect of hydro-alcoholic extract of Valeriana Officinalis on Anxiety related behavior in mice: An interaction with Serotonergic and Noradrenergic systems
S. Shen Preparation and Characterization of (3-aminopropyl)triethoxysilane-Modified Silica Nanoparticles for Protein Delivery
N. Nifantiev Phenolic Compounds From Siberian Conifer Trees – Multi-Purpose Drug Substances and Functionalized Scaffolds for Nces Design
M. Noguchi Combination Therapy of Personalized Peptide Vaccination and Low-Dose Estramustine Phosphate for Metastatic Hormone Refractory Prostate Cancer Patients
A. Rashidy-Pour Post-training administration of corticosterone enhances consolidation of contextual fear memory and hippocampal long-term potentiation in rats
I. Tvaroska Design and Synthesis of Transition State Inhibitors for Glycosyltransferases
D. Tweedie Orally Active TNF-Alpha Synthesis Inhibitors: A Role in the Treatment of Neurodegeneration?
R. Ondarza Novel Anti-Parasitic Targets from Human Pathogenic Amoebas: Entamoeba histolytica, Acanthamoeba Polyphaga and Naegleria fowleri
S. Oniga Synthesis of Some New Hydrazino-Thiazolic Compounds
M.d. Palage Synthesis and Physicochemical Characterization of Some Thiazolium 2-Aryl Ammonium Quaternary Salts
E. Topic Pharmacogenetic Approaches in Psychiatric Patients
M. K. Park An Anticancer Peptide Histonine Derived from Histonine H2A and its Mechanism of Action
S. H. Park The Absorption, Distribution, Excretion and Pharmacokinetics of Carbon-14 Labeled Pyronaridine Tetraphosphate in Sprague-Dawley Rats
B. Tiperciuc The Effect of Some New Synthesis Flavonoids on Inflammation-Induced Oxidative Stress
J. Hirsch Nanoparticle-Based Delivery of Aminoglycoside Antibiotics
A. Parvu The Effect OF Some New Chromanon-1,3,4-Oxadiazolines on Inflammation-Induced Nitric Oxide Synthesis
D. Patinkin The Effect of Pegylated Antisense Acetylcholinesterase on Hematopoiesis
J.U. Peters NK1 / NK3 Dual Antagonists: Finding a Lead for a Schizophrenia Drug Discovery Programme
M. Pinto Prenylation on Xanthonic and Flavonic Scaffolds: A Key Approach for Antitumor Activity
A. Poot Design and Synthesis of Isozyme Selective Protein Kinase C Inhibitors
M. Rosso Neurokinin 1 Receptor Antagonist Aprepitant as an Antitumor Drug
T. Kowalska On the in Vitro Oscillatory Chiral Inversion of Profen Drugs and Its Implications
Y. Takizawa Biochemical Analysis of Two Isoforms of the Human Rad51 Protein
M. Timm Cryopreservation of Differentiated HL-60 Cells – Development of a Novel in vitro Pyrogen Testing Kit
S. Sharma Synthesis, Biodistribution and Pharmacological Studies of Iozapine: A Potential Ligand for Brain Imaging
E.J. Sheridan Boronated Peptides for Boron Neutron Capture Therapy
M.E. Sousa Antiproliferative Effects and Enhancement of the Growth Inhibitory Action of 4-Hydroxytamoxifen in Estrogen Receptor Positive (ER+) Breast Cancer Cell Line Induced By Prenylated Xanthones
G.A. Spyroulias A Residue Specific Sight of Anthrax Lethal Factor – Mkks Interaction and Selectivity Towards Structure-Driven Drug Design
V. Khavinson Molecular and Genetic Mechanisms of Effect of Peptide Geroprotector Pharmaceuticals
J.-L. Peglion Benzocycloalkane Derivatives as Potent Serotonin Reuptake Inhibitors
A.F. Faruqi The Synthetic Growth Surface Topography of Ultra-Web™ Enhances Hepatocyte Culture Performance Compared to Biological Coatings
C. Fernandez Synergistic Application of NMR, MS and X-Ray for Fragment-Based Screening: A Critical Assessment
A. Kamel High Throughput Sample Analysis for Identification and Quantitative Assessment of Library Screening Using Ultra Performance Liquid Chromatography/Ultra Violet/ Evaporative Light Scattering Detection Coupled to Time of Flight Mass Spectrometry (UPLC/UV/ELSD/TOFMS)
C. Prakash Use of the Cryopreserved Human Hepatocyte Sandwich-Culture Model to Measure Hepatic Metabolism and Biliary Efflux
A. Nicolin Increase BCl2 Expression by ssRNA Complementary to the ARE Motif
E. Sletten Cytotoxic Trans- platinum Iminoether Complexes form Adducts only with Single-Stranded Oligodeoxynucleotides.


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