The 1st International Conference on Drug Design & Discovery: Dubai, February 3 - 6, 2008

Poster Program of the 1st International Conference On Drug Design & Discovery

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Tuesday, February 5, 2008

Location: Sheikh Rashid Hall A Poster Board Time: 8:30 a.m. – 7:00 p.m.
Group 1
Poster Board Reference Number
Name of Presenter Title
Ref # 1
E. Afrasiabi Anticancerous Properties of Phorbol 12-Myristate 13-Acetate (PMA) in Human Thyroid Cancer Cells
Ref # 2
Z. Zaheer Stability indicating HPTLC Determination of-Carvedilol in Pharmaceutical Dosage Form
Ref # 3
P. Alexandrino Fernandes Computational Mapping of Druggable Sites in Proteins
Ref # 4
M. Abdouss Uniformly Sized, Molecularly Imprinted Polymers for Enantioselectivity of Pseudoephedrine by Precipitation Polymerization
Ref # 5
P. Andrade HPLC-DAD-MS/MS-ESI Screening of Phenolics with Potential Bioactivity in Pieris Brassicae L. Reared on Brassica Rapa Var Rapa L.
Ref # 6
M. Alam High Throughput Compound Library Screening and Herbal Supplements to Mitigate Dengue Fever
Ref # 7
N.A. Atatreh Inhibition of Src for Potential Use in Cancer Chemotherapy
Ref # 8
A.M. Aubertin Anti-HIV Prodrugs Conjugating a Reverse Transcriptase Inhibitor with Integrase Inhibitors by a Spontaneously Cleavable Linker: Synthesis and Evaluation of Antiviral Activity
Ref # 9
M. Beiner Nanoconfinement: A strategy to manipulate the crystallization behavior of drugs
Ref # 10
N. Belacel Intelligent Decision Support System-Based Biomarker Discovery
Ref # 11
K. Orrling Investigation of the P1’ Substituent - Synthesis and Evaluation of Inhibitors of Malarial Aspartic Proteases.
Ref # 12
L. Navidpour Synthesis and Anti-helicobacter Pylori Activity of (Z)-2-(nitroimidazolylmeth-
ylene)-2(3H)-Benzofuranone Derivatives
Group 2
Ref # 13
M. Asahi Discovery of a Drug that Blocks the Trojan Horse-like Strategy Used by Pathogenic Helicobacter pylori and its Associated Bacteriophage
Ref # 14
Y.-an Bi Use of the Cryopreserved Human Hepatocyte Sandwich-Culture Model to Measure Hepatic Metabolism and Biliary Efflux
Ref # 15
D. Bikiaris Improvement of Fluvastatin Controlled Release Through the Use of New Biocompatible Aliphatic Polyesters
Ref # 16
L. Krivankova Elimination of Matrix Effects in Analyses of Trace Metabolites in Body Fluids by Capillary Electrophoresis
Ref # 17
G. Horvath Synthesis, Characterization, and Biomedical Evaluation of a Novel Water-Soluble Platinum-Based Anticancer Drug
Ref # 18
N. Bovin New Paradigm in Anti-Viral Therapy
Ref # 19
J. Breytenbach 1. Cytarabine Prodrugs for Transdermal Delivery
2. Novel Prodrugs of Lamivudine and Zidovudine for Transdermal Delivery in the Treatment of HIV/AIDS
Ref # 20
F. Burczynski Hepatoprotective Effect of Diltiazem and Silymarin.
Ref # 21
F. Carrier Molecular Understanding of Histone Deacetylase Inhibitors (HDACIs) Efficiency in Cancer Cells.
Ref # 22
L. Chalissery An Effective Purification Method for Cucurbit [N]Uril; A Molecular Host and Drug Delivery Vehicle
Ref # 23
M. Furch Allosteric Inhibitors of Myosin Function
Ref # 24
J. Du Plessis Transdermal Delivery of Arginine Vasopressin with Pheroid™ Technology
Group 3
Ref # 25
A. Chimirri Combined Ligand-Based and Target-Based Approach to Design NR2B/NMDA Receptor Antagonists
Ref # 26
J. Chin A Semi-Total Synthesis of Guggulsterones, Natural Hypolipidemic Drugs, from Various Steroids
Ref # 27
C. Soria A Novel Strategy of Anti Cancer Therapy: Targeting Specifically the Gtpase Rhoa and Development of a New Strategy for Sirna Therapy: In Vitro and In Vivo Assays
Ref # 28
S. Christensen Peptide Inhibitors of DNA Replication in Staphylococcus Aureus
Ref # 29
S. Achour Kinetic study on the Decomposition of 2-Chloroethylnitrososulfamides (CENS) in Organic Media
Ref # 30
E. Valeur Dual Fragment Microarrays : Towards a New Perspective for Drug Discovery
Ref # 31
M. Correia-da-Silva Anticoagulant Actions of Structure-Diverse Sulfated Phenols
Ref # 32
R. Dghaim Palladium Catalyzed Multicomponent Reactions: A Facile One-Pot Coupling Approach to α-Amino Acid and Peptide Derivatives
Ref # 33
H. Doi Pd(0)-Mediated Rapid C-Methylations for the Synthesis of 11C-Incorporated PET Tracerrs
Ref # 34
G. Duburs Peptide-Like and Lipid-Type Compounds on the Basis of Unsaturated Cyclic Amino Acids-Carbonyldihydropyridines
Ref # 35
H. Durchschlag Modeling of Individual Water Molecules Preferentially Bound to Proteins
Group 4
Ref # 36
D. Egan Apoptotic Cell Death and Cell Cycle Events Mediate the Action of 6-Hydroxycoumarin-3-Carboxylatosilver in Human Malignant Hepatic Cells
Ref # 37
B. Flynn Discovery of BNC105P, A Clinical Candidate for the Treatment of Cancer: A Case Study in the Application of the Diversity-Oriented Synthesis Technology, MultiCore®
Ref # 38
E. Fagadar-Cosma New Asymmetric meso-Tetraphenylporphyrins Peripherally Diverse Substituted with Pyridyl or Dimethoxy Groups as Promising Photosensitizers in Photodynamic Therapy
Ref # 39
A. Siriviat Electric Field Drive Transdermal Drug Delivery of Salicylic Acid -Loaded Polyacrylamide Hydrogels
Ref # 40
I.M. Fenyo Retinoids Induce Apoe Gene Upregulation in Macrophages
Ref # 41
P. Kothary Greater Inhibition of Connective Tissue Growth Factor Synthesis By a MAP Kinase Inhibitor Compared to Amino Guanidine in Cultured Human Retinal Pigment Epithelial Cells
Ref # 42
S. Gobec New Inhibitors of D-Alanine:D-Alanine Ligase (Ddlb) Discovered By Structure-Based Virtual Screening of the NCI Diversity Set
Ref # 43
K. Goracinova Efficacy of Microparticulated Bds Dosage Forms in the Treatment of Experimentally Induced Colitis in Rats
Ref # 44
T. Kowalska On the In Vitro Oscillatory Chiral Inversion of Selected L-Amino Acids and its Implications.
Ref # 45
K. Shayesteh Powder Mixing and Influence of Solvent on Mixture Quality in the Production of Amlodipin Tablet
Ref # 46
H.R. Ha Chemical Structure-Aqueous Solubility Relationship of Amiodarone
Group 5
Ref # 47
G. Hadzic Dynasore is not Dynamin Inhibitor
Ref # 48
V. Khavinson Peptide Regulation of the Functional Activity of the Retina
Ref # 49
E.W. Hansen A Novel Human-Cell Based Pyrogen Test
Ref # 50
R. Akkina A New Humanized Mouse Model for Testing HIV/AIDS Therapies and Microbicides
Ref # 51
M.Y. Yoon Overexpression of Tubulin and its Inhibitor Screening for Microtubule Formation in Phytophthora Capsici
Ref # 52
M. Hassan Antineoplastic Effects of α-Terpineol, Linalyl Acetate and dl-Camphor, Components of Lebanese Sage Essential Oil
Ref # 53
R. Ward Correlation of Activity and Sequence Similarity in Kinase Targets
Ref # 54
S. Hassan Antineoplastic Effects of α-Terpineol, Linalyl Acetate and Dl-Camphor, Components of Lebanese Sage Essential Oil
Ref # 55
K. Musilek Acetylcholinesterase Reactivator – Oxime HI-6 – Antidote Against Nerve Agents
Ref # 56
H. Hibasami Blazein (A New Steroid) Isolated from Mushroom (Agaricus blazei Murill) Induce Apoptosis in Human Lung Cancer LU99 and Stomach Cancer KATO III Cells
Ref # 57
T. Bruckdorfer PEGylation – A Key Technology to improve Solubility and Pharmacokinetic of Peptides, Proteins and other Biopharmaceuticals for Superior Drug Delivery
Group 6
Ref # 58
M. Steiert Nanoparticle-Based Delivery of Aminoglycoside Antibiotics
Ref # 59
S. Imreh A Microcell Hybrid Based "Elimination Test" in Anticancer Drug Design
Ref # 60
D. Janezic Protein-Protein Binding Sites Prediction
Ref # 61
G.A. Spyroulias Novel Insights into Angiotensin-Converting Enzyme Domain Selectivity & Structure-Based Drug Design
Ref # 62
K. Al-Kuraya Ubiquitin-Ligase SKP2 Pathway is an Attractive Target for Colorectal Cancer Therapy
Ref # 63
A. Helgee A Method for Automated Molecular Optimization by Inverse QSAR Applied to Ames Mutagenicity Data
Ref # 64
R. Kamel Polymeric Matrix System for Transdermal Delivery of Tramadol Hydrochloride
Ref # 65
S. Kanan Detection and Identification of Banned Chemicals in Dietary Food Supplements
Ref # 66
E. Karavas Hydrogen Bonding Interactions as a New Sustain Release Mechanism
Ref # 67
J. Kasparkova Unique Properties of DNA Interstrand Cross-Links of Antitumor Oxaliplatin
Ref # 68
J. Kelly Can the Acute Toxicity of Antidepressants be Predicted Using the Protozoan Tetrahymena pyriformis?

Wednesday, February 6, 2008

Location: Sheikh Rashid Hall A Poster Board Time: 8:30 a.m. – 7:00 p.m.
Group 7
Ref # 69
A. Sirivat Controlled Release of Sulfosalicylic Acid from Polypyrrole/Poly(acrylic acid) Hydrogel by Electrical Stimulation
Ref # 70
J. Garmendia β2 Adrenoreceptor Polymorphism in Asthmatic Population in Venezuelan
Ref # 71
A. Khvat Rational for Focused DiversityTM Approach to Discovery of Signaling and Developmental Pathway Inhibitors. A Case Study for PI3K and Hh Modulators
Ref # 72
L. Carlsson Local Interpretation of Machine-Learning Models using Attribute Gradients, Applied to Ames Mutagenicity Data
Ref # 73
P. Ohrngren Evaluation of Various P1’ Substituents in Tertiary Alcohol Containing and Elongated HIV-1 Protease Inhibitors
Ref # 74
O. Lagerlund α-Arylation of a Protected Glycine in Water: 3-Phenylglycine Derivatives as Inhibitors of the Tuberculosis Enzyme, Glutamine Synthetase
Ref # 75
L. Kock Aspirin: The Anti-Inflammatory Antifungal
Ref # 76
A. Vakili Effect of central blockage of gap junction by Carbenoxolone on ischemic damage in transient model of focal cerebral ischemia
Ref # 77
S. Komba General Strategy for Synthesis of Oligosaccharide Combinatorial Library to Develop for Oligosaccharide Array
Ref # 78
H. Fessi Preparation and Characterization of Radioactive Dirhenium Decacarbonyl-Loaded PLLA Nanoparticles for Radionuclide Intra-Tumoral Therapy
Ref # 79
E. Valeur Towards Potent Inhibitors of the Mdm2-P53 Protein-Protein Interaction
Group 8
Ref # 80
J.S. Kovach A New Inhibitor of Serine-Threonine Protein Phosphatase, PP2A, Suppresses
Growth and Induces Differentiation of Medulloblastoma Cells
Ref # 81
M. Asahi Therapy against Microbial-Encoded ITAM-Like Motifs May Treat and/or Prevent a Number of Serious Infections Caused by Microbial Pathogens
Ref # 82
M. Kukhanova Design of Depot Forms of Anti-Hiv Agents Based on Nucleoside -Phosphonate Derivatives
Ref # 83
G. Kulcsar Preclinical Experiments on Culevit Infusion Developed on the Basis of a Passive Antitumor Defence System and Investigation of Mechanism
Ref # 84
K.L. Lou Improvement of Drug Virtual Screen By GA/GP: Docking Studies on Tubulin Inhibitors as Anticancer Agents
Ref # 85
B. Lammek Influence of Bulky 3, 3- Diphenylalanine Enantiomers Replacing Position 2 of Arginine Vasopressin and its Analogues on their Pharmacological Properties
Ref # 86
E. El-Bastawiss Molecular Docking and Analysis of Certain Potent Anti-angiogenic Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Inhibitors
Ref # 87
F. Lefranc Narciclasine Displays Potent and Selective Anti-Tumor Effects by Impairing Cancer Cell Migration Through a Phosphocofilin-Mediated Increase of Actin Stress Fibers
Ref # 88
W. Liebenberg An In vitro Evaluation of the Efficacy of Anti-Malaria Drugs by Pheroid™ Technology
Ref # 89
J.C. Lin Inhibitory Effects of Some Derivatives of Glycyrrhizic Acid against Epstein-Barr Virus Infection: Structure-Activity Relationships
Ref # 90
M. Lise Effect of Moist Heat Sterilisation on Pyrogenicity of Whole Bacteria and Cell Wall Components from Staphylococcus aureus
Group 9
Ref # 91
Z. Zidek Novel Group of Biological Response Modifiers: Inhibitors of Endoplasmic Ca2+-ATPase
Ref # 92
A.A. Taherian Comparison the effects of aqueous extract of Glycyrrhiza Glabra, Dexamethasone and stress on acute and chronic pains in mice
Ref # 93
M. Degani Synthesis and Biological Evaluation of Novel Antifolates Towards Filariasis
Ref # 94
Y. Zhao Cucurbit[N] Uril for Drug Delivery
Ref # 95
A. Maghazachi The Copolymer-1 Glatiramer Acetate (Copaxone) Inhibits Natural Killer (NK) Cells Lysis of Tumor Cells but Enhances Their Cytolysis of Syngeneic or Allogeneic Immature and Mature Monocyte-Derived Dendritic Cells
Ref # 96
R. Müller Action of Disorazol A in Combination with Other Tubulin-active Compounds
Ref # 97
N. Belacel Theoretical Analysis of Metabolic Pathways in Cancer Development - The Effect of Zn2+ Concentration Changes on Prostate Cell Metabolism - Authored by Miroslova Cuperlovic-Culf and Nabil Belacel
Ref # 98
B. Zhang In Silico Protein-Protein Interaction Peptide Inhibitors Design for Cyclin-Dependent Kinase5 (CDKs)
Ref # 99
M.C.Manca de Nadra Viability Modification of Listeria Monocytogenes by the Effect of Phenolic Compounds Combination
Ref # 100
J. Bappu A Novel Therapeutic Use of Fibrin Sealant to Promote Saphenous Graft Wound Healing in Patients Undergoing Cardiac Surgery: A Randomised Study
Ref # 101
A. Khalid Searching for New Cholinesterases Inhibiting Drug Candidates from Natural Sources
Group 10
Ref # 102
A. Yarat Investigation of the Effect of Silymarin on the Liver in Experimental Sepsis
Ref # 103
E. Mohamed Probing the HIV Reverse-Transcriptase Enzyme: Synthesis and Biological Evaluation of Novel Bifunctional NRTI/NNRTI HIV-1 Reverse-Transcriptase Inhibitors
Ref # 104
A. S. Yang Molecular Modeling of Protein-Substrate Interactions in Factor-Xa with High-Throughput Substrate Phage-Display Data
Ref # 105
M. Muñoz Neurokinin 1 Receptor Antagonist Aprepitant as an Antitumor Drug
Ref # 106
P. Muretto Endogastric Capsule for E-Cadherin Gene (CDH1) Promoter Hypermethylation Assessment in DNA from Gastric Juice of Patients with Gastric Cancer
Ref # 107
A. A. Vafaei Effect of hydro-alcoholic extract of Valeriana Officinalis on Anxiety related behavior in mice: An interaction with Serotonergic and Noradrenergic systems
Ref # 108
S. Shen Preparation and Characterization of (3-aminopropyl)triethoxysilane-Modified Silica Nanoparticles for Protein Delivery
Ref # 109
N. Nifantiev Phenolic Compounds From Siberian Conifer Trees – Multi-Purpose Drug Substances and Functionalized Scaffolds for Nces Design
Ref # 110
M. Noguchi Combination Therapy of Personalized Peptide Vaccination and Low-Dose Estramustine Phosphate for Metastatic Hormone Refractory Prostate Cancer Patients
Ref # 111
A. Rashidy-Pour Post-training administration of corticosterone enhances consolidation of contextual fear memory and hippocampal long-term potentiation in rats
Ref # 112
I. Tvaroska Design and Synthesis of Transition State Inhibitors for Glycosyltransferases
Group 11
Ref # 113
D. Tweedie Orally Active TNF-Alpha Synthesis Inhibitors: A Role in the Treatment of Neurodegeneration?
Ref # 114
R. Ondarza Novel Anti-Parasitic Targets from Human Pathogenic Amoebas: Entamoeba histolytica, Acanthamoeba Polyphaga and Naegleria fowleri
Ref # 115
S. Oniga Synthesis of Some New Hydrazino-Thiazolic Compounds
Ref # 116
M.d. Palage Synthesis and Physicochemical Characterization of Some Thiazolium 2-Aryl Ammonium Quaternary Salts
Ref # 117
E. Topic Pharmacogenetic Approaches in Psychiatric Patients
Ref # 118
M. K. Park An Anticancer Peptide Histonine Derived from Histonine H2A and its Mechanism of Action
Ref # 119
S. H. Park The Absorption, Distribution, Excretion and Pharmacokinetics of Carbon-14 Labeled Pyronaridine Tetraphosphate in Sprague-Dawley Rats
Ref # 120
B. Tiperciuc The Effect of Some New Synthesis Flavonoids on Inflammation-Induced Oxidative Stress
Ref # 121
J. Hirsch Nanoparticle-Based Delivery of Aminoglycoside Antibiotics
Ref # 122
A. Parvu The Effect OF Some New Chromanon-1,3,4-Oxadiazolines on Inflammation-Induced Nitric Oxide Synthesis
Ref # 123
D. Patinkin The Effect of Pegylated Antisense Acetylcholinesterase on Hematopoiesis
Group 12
Ref # 124
J.U. Peters NK1 / NK3 Dual Antagonists: Finding a Lead for a Schizophrenia Drug Discovery Programme
Ref # 125
M. Pinto Prenylation on Xanthonic and Flavonic Scaffolds: A Key Approach for Antitumor Activity
Ref # 126
A. Poot Design and Synthesis of Isozyme Selective Protein Kinase C Inhibitors
Ref # 127
M. Rosso Neurokinin 1 Receptor Antagonist Aprepitant as an Antitumor Drug
Ref # 128
T. Kowalska On the in Vitro Oscillatory Chiral Inversion of Profen Drugs and Its Implications
Ref # 129
Y. Takizawa Biochemical Analysis of Two Isoforms of the Human Rad51 Protein
Ref # 130
M. Timm Cryopreservation of Differentiated HL-60 Cells – Development of a Novel in vitro Pyrogen Testing Kit
Ref # 131
S. Sharma Synthesis, Biodistribution and Pharmacological Studies of Iozapine: A Potential Ligand for Brain Imaging
Ref # 132
E.J. Sheridan Boronated Peptides for Boron Neutron Capture Therapy
Ref # 133
M.E. Sousa Antiproliferative Effects and Enhancement of the Growth Inhibitory Action of 4-Hydroxytamoxifen in Estrogen Receptor Positive (ER+) Breast Cancer Cell Line Induced By Prenylated Xanthones
Ref # 134
G.A. Spyroulias A Residue Specific Sight of Anthrax Lethal Factor – Mkks Interaction and Selectivity Towards Structure-Driven Drug Design

Thursday, February 7, 2008

Location: Sheikh Rashid Hall A Poster Board Time: 8:30 a.m. – 7:00 p.m.
Group 13
Poster Board Reference Number
Name of Presenter Title
Ref # 135
V. Khavinson Molecular and Genetic Mechanisms of Effect of Peptide Geroprotector Pharmaceuticals
Ref # 136
J.-L. Peglion Benzocycloalkane Derivatives as Potent Serotonin Reuptake Inhibitors
Ref # 137
A.F. Faruqi The Synthetic Growth Surface Topography of Ultra-Web™ Enhances Hepatocyte Culture Performance Compared to Biological Coatings
Ref # 138
C. Fernandez Synergistic Application of NMR, MS and X-Ray for Fragment-Based Screening: A Critical Assessment
Ref # 139
A. Kamel High Throughput Sample Analysis for Identification and Quantitative Assessment of Library Screening Using Ultra Performance Liquid Chromatography/Ultra Violet/ Evaporative Light Scattering Detection Coupled to Time of Flight Mass Spectrometry (UPLC/UV/ELSD/TOFMS)
Ref # 140
C. Prakash Use of the Cryopreserved Human Hepatocyte Sandwich-Culture Model to Measure Hepatic Metabolism and Biliary Efflux
Ref # 141
A. Nicolin Increase BCl2 Expression by ssRNA Complementary to the ARE Motif
Ref # 142
E. Sletten Cytotoxic Trans- platinum Iminoether Complexes form Adducts only with Single-Stranded Oligodeoxynucleotides.

Closing Ceremony: 7:00 - 7:30 p.m.

Refreshment: 7:30 p.m.
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