The 1st International Conference on Drug Design & Discovery: Dubai, February 3 - 6, 2008





 
Scientific Program of the 1st International Conference On Drug Design & Discovery
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Lecture Key:
Nobel Lecture Plenary Lecture Invited Lecture Session Lecture

Note: Please click the title to view the abstracts

Monday, February 4, 2008

Location: Sheikh Rashid Hall B

Chairman: J.R. Warren Co-Chairman: Atta-ur-Rahman
Time Name of Speaker Title
11:30 - 12:15 p.m. M. Abou-Gharbia Discovery of Innovative Therapeutics: The Pharma Perspective
12:15 - 01:00 p.m. K. Wuthrich Structural Biology and Structural Genomics in Drug Discovery

LUNCH BREAK : 1:00 - 2:30 p.m.

Location: Sheikh Rashid Hall B

Chairman: M. Abou-Gharbia Co-Chairman: R. Dolle
2:30 – 3:00 p.m. S. Edmondson Discovery of JANUVIA™ (Sitagliptin): A Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
3:00 – 3:30 p.m. J. Maibaum Structure-based Discovery of Aliskiren - A Direct Renin Inhibitor for Hypertension Therapy

Location: Sheikh Rashid Hall C

Chairman: H. Kroto Co-Chairman: P. Talaga
2:30 – 3:00 p.m. B. M. Dunn The Structural and Biochemical Properties of Non-B Subtype HIV-1 Proteases and Drug Resistance
3:00 – 3:30 p.m. H. Kurumizaka Structural and Biochemical Studies of Homologous Recombination toward Drug Design and Discovery

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: A. P. Kozikowski Co-Chairman: C. Prakash
2:30 – 3:00 p.m. C.R. Cantor Pharmacogenetics Using an Automated Mass Spectrometry Platform for DNA Analysis
3:00 – 3:30 p.m. K. Fujita Pharmacogenomics in Drug-Metabolizing Enzymes: For Personalized Cancer Chemotherapy

Location: Umm Al Quwain Hall (Upstairs)


Chairman: J. Deisenhofer Co-Chairman: I. Toth
2:30 – 3:00 p.m. P. Nielsen Towards Novel Gene Targeted Drugs. Progress in dsDNA Recognition and Cellular Delivery of Peptide Nucleic Acid (PNA)
3:00 – 3:30 p.m. L. Corcoran Functional Characterisation of New Immunomodulatory Compounds

COFFEE BREAK : 03.30 – 4.00 p.m. (Sheikh Rashid Hall D)

Location: Sheikh Rashid Hall B


Chairman: M. Veltman Co-Chairman: A. Al-aboudi
4:00 – 4:30 p.m. T. Mansour Antibiotics from Natural Products: Discovery of Tygacil®
4:30 – 5:00 p.m. D.A. Burnett The Discovery of Cholesterol Absorption Inhibitors: From ACAT to Zetia
5:00 – 5:30 p.m. N. Oku Cancer Antineovascular Therapy by use of Angiogenic Vessel-targeted Liposomal Drugs
5:30 – 6:00 p.m. J. Kardos Glial Glutamate and GABA Transporters as Neuroprotective Targets
6:00 – 6:20 p.m. P. Boulikas Tumor-Targeted Liposomal Cisplatin (Lipoplatin™) and Oxaliplatin (Lipoxal™) show Superiority to Free Drugs: from Inception to Phase III
6:20 – 6:40 p.m. G. Campiani Development of Potent Atypical Antipsychotics based on A Novel Neurochemical Approach
6:40 – 7:00 p.m. P. Talaga Frontiers in Medicinal Chemistry. Time for another Big Bang?

Location: Sheikh Rashid Hall C


Chairman: K. von Klitzing Co-Chairman: A. Rahman
4:00 – 4:30 p.m. A. Maggi Reporter mice and Drug Discovery and Development
4:30 – 5:00 p.m. F. Maina HIT MetASTASIS: Unbalancing Met Activity and its Downstream Survival Signals for new Anticancer Therapies
5:00 – 5:30 p.m. J. Zheng Structure-based Investigation of Wnt Signaling Inhibitors
5:30 – 6:00 p.m. E. Pai From Enzyme Mechanism Studies to the Generation of Lead Compounds against Malaria
6:00 – 6:20 p.m. N. Pugno Smart Flexible Nanovectors
6:20 – 6:40 p.m. G. Osuji Discovery of the RNA Synthetic Activity of Glutamate Dehydrogenase and Application in Drug Metabolism
6:40 – 7:00 p.m. A.D.N. Vaz Aldehyde Oxidase in Drug Metabolism: Simple Preclinical Tests to Avoid Potential for Clinical Pharmacokinetic Failure

Location: Ras Al Khaimah Hall (Upstairs)


Chairman: C. Cantor Co-Chairman: M.I. Choudhary
4:00 – 4:30 p.m. H.J. Guchelaar A Clinical Pharmacogenetic Model to Predict the Efficacy of Methotrexate Monotherapy in Recent-Onset Rheumatoid Arthritis
4:30 – 5:00 p.m. M.S. Lee The Effects of Genes Related to the Monoaminergic Pathway on the Action of Antidepressants
5:00 – 5:30 p.m. T. Ouchi Translational Approach to Study Anti-Cancer Drugs Using Mouse Model of Breast Cancer
5:30 – 6:00 p.m. J. St-Amand High Throughput Functional Genomics Strategy to Discover New Therapeutic Targets for Complex Diseases
6:00 – 6:20 p.m. A. Milosavljevic A Comprehensive Map of Chromosomal Aberrations in the MCF-7 Breast Cancer Cell Line Genome: Technology, Informatics, and Significance
6:20 – 6:40 p.m. F.M. Veronese Therapeutic Proteins: New Achievements for Stabilization and Delivery
6:40 – 7:00 p.m. B. Roca (Villanueva) Pharmacogenomics of Antiretrovirals

Location: Umm Al Quwain Hall (Upstairs)


Chairman: D. Craik Co-Chairman: M. Suzuki
4:00 – 4:30 p.m. I. Toth Vaccine Delivery: Synthesis and Investigation of a Highly Pure, Multi-Epitopic Lipopeptide Vaccine Candidate
4:30 – 5:00 p.m O. Alpar New delivery challenges: Nanocarriers for the Delivery of siRNA
5:00 – 5:30 p.m. P. Artursson Profiling and Prediction of Drug Transporter Interactions
5:30 – 6:00 p.m. A. Bernkop-Schnuerch Multifunctional Polymeric Excipients: The Key for Oral Delivery of Peptides and Nucleic Acids?
6:00 – 6:20 p.m. D. Grainger
Title Awaited
6:20 – 6:40 p.m. P.G.M. Rao Adverse Drug Reactions among Hospitalized Patients in Nephrology Wards-An Intensive Monitoring Study
6:40 – 7:00 p.m. K. Yasuda
Title Awaited


Tuesday, February 5, 2008

Location: Sheikh Rashid Hall B

Chairman: B.M. Dunn Co-Chairman: P. Nielsen
Time Name of Speaker Title
8:30 – 9:15 a.m. S.T. Furlong The Challenges of Implementing Biomarkers in Clinical Trials
9:15 – 10:00 a.m. Atta-ur-Rahman FRS Some Adventures in Chemistry and Education
10:00 – 10:45 a.m. E. De Clercq Current Drugs for the Treatment of HIV Infection (AIDS) Role of Acyclic Nucleoside Phosphonates

COFFEE BREAK : 10:45 – 11:30 a.m. (Sheikh Rashid Hall D)

Location: Sheikh Rashid Hall B

Chairman: I. Toth Co-Chairman: T. Ruckle
11:30–12:00 noon D. Craik Cyclotides as a Peptide-Based Combinatorial Template for Drug Design
12:00 – 12:30 p.m. T. Rades Nanoparticles As Delivery Systems For Subunit Vaccines - A Pharmaceutical Approach
12:30 – 1:00 p.m. M. Roberts Targeted Topical Drug Delivery
1:00 – 1:30 p.m. R. Dolle Single-Step N-Heterocyclic Annulation Reactions for High Throughput Chemistry

Location: Sheikh Rashid Hall C

Chairman: K. Izuhara Co-Chairman: M. Barton
11:30–12:00 noon S. van Calenbergh Synthesis of Fosmidomycin Analogues: Towards Potent Antimalarials
12:00 – 12:30 p.m. T.M.S. Chang Novel Nanomedicine Based Therapeutics
12:30 – 1:00 p.m. A. Cherkasov Cheminformatics Delivers Super-antibiotics for Superbugs
1:00 – 1:30 p.m. B. Fowler
 Development and Validation of Emerging “Omic” Biomarkers for New Drugs: An Overview of Lessons Learned from High Technology Materials

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: P. Talaga Co-Chairman: M.S. Shekhani
11:30–12:00 noon T. Hogberg Novel Design Principles fro GPCR Specific Libraries
12:00 – 12:30 p.m. G. Bertho The Expanding Role of NMR in the Early Steps of Drug Design and Discovery
12:30 – 1:00 p.m. J.R. Hwu New Bionano Materials for Drug Delivery
1:00 – 1:30 p.m. I. Ojima Design, Application, and Chemical Biology of Tumor-Targeting Drug Conjugates

Location: Umm Al Quwain Hall (Upstairs)

Chairman: A. Mjalli Co-Chairman: W. Banks
11:30–12:00 noon C. Prakash Strategies for the Selection of Drug Candidates for Development: An Overview
12:00 – 12:30 p.m. E. Arinc Cytochrome P450 Dependent Drug Metabolism and Outcomes of Drug-Drug Drug-Toxicant Interactions in Diabetes
12:30 – 1:00 p.m. K. Beaumont Mitigating the Reactivity of Acyl Glucuronides in a NEPi Discovery Programme
1:00 – 1:30 p.m. A. Kalgutkar The Role of Drug Metabolism and Drug Transport in Idiosyncratic Adverse Drug Reactions

LUNCH BREAK : 01:30 – 2:30 p.m.

Location: Sheikh Rashid Hall B

Chairman: S. Tkachenko Co-Chairman: O. Alpar
2:30 – 2:50 p.m. K.K.W. Wang New Theranostic Approach to Diagnose and Treat Traumatic Brain Injury
2:50 – 3:10 p.m. R. Minchin Multi-Component Peptide-Based Carriers for Non-Viral DNA Delivery
3:10 – 3:30 p.m. F. Darvas Enabling Novel Technologies to Expedite Medicinal Chemistry: Combination of Flow Synthesis and Serendipity-Enhancing Technics for Lead Discovery
3:30 – 3:50 p.m. Y. Perrie Delivering DNA and Protein Antigens – A Role For Cationic Liposomes
3:50 – 4:10 p.m. P. Simerska Vaccines against group A Streptococcal Infection and Human Papillomavirus Type-16 associated Cervical Cancer
4:10 – 4:30 p.m. M. Stenzel Crosslinked Micelles via the Raft Process: Towards a more Biocompatible Gene Delivery System

Location: Sheikh Rashid Hall C

Chairman: S.T. Furlong Co-Chairman: M. Sinz
2:30 – 2:50 p.m. E. Gordon Integrating Gene-Brain-Behaviour Markers for the era of ‘Personalized Medicine’
2:50 – 3:10 p.m. E. Kmonickova Nitric Oxide as a Biomarker of Immunostimulatory Activity of Drugs
3:10 – 3:30 p.m. Y. Korpan Cancer Diagnostic and Prognostic: European Research Strategies, Recent Sensor Achievements and New Targets
3:30 – 3:50 p.m. R. McDade Following the Critical Path: Development of Multi-Analyte Profiles for Sensitive, Early Detection of Toxicity
3:50 – 4:10 p.m. S. Mukaddam-Daher Cardiac Imidazoline Receptors, a New Therapeutic Target
4:10 – 4:30 p.m. K.S.A. Khabar Molecular Response to Therapeutic Interferons: Sensitivity and Resistance Mechanisms

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: K. Hasegawa Co-Chairman: G. Brooks
2:30 – 2:50 p.m. M. Yoshioka Identification and Characterization of Therapeutic Targets for Prostate Cancer
2:50 – 3:10 p.m. B. Rochat Role and Importance of Hepatic and Extrahepatic Drug Metabolizing Enzymes in the Bioavailability of Anti-Cancer Agents in Cancer Cells
3:10 – 3:30 p.m. V. Apostolopoulos Peptide based Vaccines: A Structural and Immunological Perspective
3:30 – 3:50 p.m. U. Bachrach Imino-aldehydes- a new tool to Combat Cancer and Viral Diseases
3:50 – 4:10 p.m. U. Baltayev Antiulcer and Cardiovascular Compounds(steroids): Structure Activity
4:10 – 4:30 p.m. A.J. Mendonca Novel Building Blocks and Templates for GPCR and Kinase Research

Location: Umm Al Quwain Hall (Upstairs)

Chairman: P. Nielsen Co-Chairman: T. M.S. Chang
2:30 – 2:50 p.m. C. Maercker Inducible Nidogen Expression in Epidermal HACAT Cells
2:50 – 3:10 p.m. J. Nielsen Synthesis of Bioactive Natural Products
3:10 – 3:30 p.m. V. Sakanyan Development of Small Molecule and Antibody Microarrays Designed for Drug Discovery
3:30 – 3:50 p.m. In-C. Kang High-Performance Screening of Active Peptide Inhibitor of Integrin Receptor by Protein Microarray Chip
3:50 – 4:10 p.m. J. Tavernier The MAPPIT Toolbox: Strategies to Analyze Molecular Interactions in Intact Cells
4:10 – 4:30 p.m. A. Yuryev In Silico Pathway Analysis: The Final Frontier Towards Completely Rational Drug Design

COFFEE BREAK : 04:30 – 5:00 p.m. (Sheikh Rashid Hall D)

Location: Sheikh Rashid Hall B

Chairman: A. Maggi Co-Chairman: J. Kardos
5:00 – 5:20 p.m. S. Hannongbva
Title Awaited
5:20 – 5:40 p.m. J. Turnbull “Engineered Heparins”: Novel Beta-Secretase Inhibitors as Potential Therapeutics for Alzheimer's Disease
5:40 – 6:00 p.m. B. Potter Steroid Sulfatase Inhibitors: From Concept to Clinic
6:00 – 6:20 p.m. A. Tsarbopoulos
Title Awaited
6:20 – 6:40 p.m. S. Krol
Title Awaited
6:40 – 7:00 p.m. M.S. Shekhani Using Sugars in Drug Discovery

Location: Sheikh Rashid Hall C

Chairman: X. Morelli Co-Chairman: B. Fowler
5:00 – 5:20 p.m. E. Carrier Artificial Hematopoietic Stem Cell Niche Sustains Growth and Differentiation of Human ES-Dervied Early Hematopoietic Pregenitors
5:20 – 5:40 p.m. Y. Kitade Synthesis of 2', 5' -Oligoadenylates Having Aromatic Groups and their Biological Activities
5:40 – 6:00 p.m. S. Dastmalchi Prediction of Structural Features of Integral Membrane Proteins
6:00 – 6:20 p.m. I.A. Bashir The use of gum arabic fraction for treatment of chronic renal failure patients
6:20 – 6:40 p.m. A. Khalid From Molecular Recognition to Drug Design:Applications of Experimental and Theoretical Enzyme Inhibition Studies
6:40 – 7:00 p.m. K. Fox Towards the Targeted Modulation of Gene Expression by Modified Triplex-Forming Oligonucleotides

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: K. Beaumont Co-Chairman: J. Zheng
5:00 – 5:20 p.m. K. Suzuki Protein C Inhibitor Regulates Breast Cancer Cell Growth, Metastasis and Angiogenesis
5:20 – 5:40 p.m. F. Vallette Apoptosis as a Target for Peptide and Protein Therapies
5:40 – 6:00 p.m. A. Al-aboudi Cholinesterases Inhibitory Activity of Testosterone and Some of its Metabolites
6:00 – 6:20 p.m. M.A. Eldaway Design Studies of Drugs for the Management of Certain
Parasitic and Hepatic Viral Infections
6:20 – 6:40 p.m. C.W. Huck
Title Awaited
6:40 – 7:00 p.m. B. Coulombe Inhibitors of Multisubunit RNA Polymerases as Tools to Study Transcriptional Mechanisms in Prokaryotes and Eukaryotes

Location: Umm Al Quwain Hall (Upstairs)

Chairman: S. Van Calenbergh Co-Chairman: M. Preobrazhenskaya
5:00 – 5:20 p.m. A.H. Al-Marzouqi Effect of Preparation Method on Physicochemical Properties of Antifungal Drug-Cyclodextrin Complexes - Comparison between Supercritical Carbon Dioxide and Conventional Methods
5:20 – 5:40 p.m. C. Berthelette Case Study of DP Receptor Antagonists: From HTS to Synthesis and Selection of Pre-Clinical Candidate Compounds
5:40 – 6:00 p.m. J. Bandow Identification and Characterization of Novel Antibiotic Targets
6:00 – 6:20 p.m. C.-H. Lai The Asian Gynecologic Oncology Group and Clinical Trial Center of Chang Gung Memorial Hospital
6:20 – 6:40 p.m. H. Gardsvoll Mapping Structural and Functional Epitopes for Ligand and Monoclonal Antibody Binding on the Receptor for Urokinase-Type Plasminogen Activator: Identification of Potential Target Sites for Antagonist-Based Cancer Therapy
6:40 – 7:00 p.m. V. Gault GIP-Based Therapeutics for Diabetes and Obesity

LOCATION: Sheikh Rashid Hall A
POSTER SESSION : 6:00 – 7:00 p.m.


Wednesday, February 6, 2008

Location: Sheikh Rashid Hall B

Chairman: A. Cherkasov Co-Chairman: L. Corcoran
Time Name of Speaker Title
8:30 – 9:15 a.m. K. Izuhara Inflammation and Allergy Drug Design and Discovery: Search for Novel Drug Targets for Bronchial Asthma by Microarray Approach
9:15 – 10:00 a.m. A. Reitz BACE Inhibitors for the Treatment of Alzheimer’s Disease

Location: Sheikh Rashid Hall B

Chairman: A. Reitz Co-Chairman: T. Mansour
10:00 – 10:30 a.m. W. Banks Transport of Antisense across the Blood-Brain Barrier
10:30 – 11:00 a.m. M. I. Choudhary Nature - Source of New Pharmacophores
11:00 – 11:30 a.m. G. Whitlock Serotonin/Noradrenaline Reuptake Inhibitors: A Case History in the Challenges of CNS Drug Discovery
11:30 – 12:00 noon A. Kozikowski Histone Deacetylase Inhibitors, Neuroprotection, and CNS Disorders

Location: Sheikh Rashid Hall C

Chairman: E. De Clercq Co-Chairman: A. Maggi
10:00 – 10:30 a.m. J.M. Brunel Stereoselective Synthesis of Squalamine Analogues: Evaluation of their Antimicrobial Activities
10:30 – 11:00 a.m. K. Hostetler Alkoxyalkyl Acyclic Nucleoside Phosphonates for Smallpox and other Viral Diseases
11:00 – 11:30 a.m. M. Preobrazhenskaya Chemistry and Biology of Glycopeptide Antibiotics
11:30 – 12:00 noon S. Nwaka Global Networks for Drug Discovery for Infectious Tropical Diseases

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: K. Izuhara Co-Chairman: H.J. Guchelaar
10:00 – 10:30 a.m. Y. Al-Abed Identification of MIF’s Proinflammatory Site: A Novel Target for Drug Discovery in Autoimmune and Inflammatory Diseases
10:30 – 11:00 a.m. O. El-Agnaf A Strategy for Designing and Screening Inhibitors of α -Synuclein Aggregation and Toxicity: As a Novel Treatment for Parkinson's Disease
11:00 – 11:30 a.m. F. Nyberg The Substance P System as a Target in the development of Peptidomimetics acting as Potential Pain Relievers and as Drugs for Treatment of Opiod Addiction
11:30 – 12:00 noon H. Renz Development of new Therapeutic approaches in Allergy and Lung Disease: The Antisense Strategies

Location: Umm Al Quwain Hall (Upstairs)

Chairman: L. Corcoran Co-Chairman: P. Artursson
10:00 – 10:30 a.m. X. Wehrens Intracellular Calcium Release Channels - Promising Targets for the Treatment of Heart Failure And Arrhythmias
10:30 – 11:00 a.m. G. Brooks Targeting the Cell Cycle Machinery for Cardiac Regeneration
11:00 – 11:30 a.m. J. Gibbins Innovations in the Development of Anti-Platelet Therapies for the Prevention of Thrombosis
11:30 – 12:00 noon K. Hasegawa A Pharmacological Heart Failure Therapy that Targets Nuclear Pathway in Cardiac Myocytes

COFFEE BREAK : 12:00 – 12:30 p.m. (Sheikh Rashid Hall D)

Location: Sheikh Rashid Hall B:

Chairman: L. Ghosez Co-Chairman: F. Nyberg
12:30 – 1:00 p.m. M. Waring The Long March towards Effective and Selective Drug Treatment of Cancer
1:00 – 1:30 p.m. P. Herdewijn Chemical Modified Sirna for the Inhibition of P-Glycoprotein Expression
1:30 – 2:00 p.m. S. Ingvarsson Genomic Instability in Breast Cancer

Location: Sheikh Rashid Hall C

Chairman: E. Pai Co-Chairman: G. Bertho
12:30 – 1:00 p.m. A. McCluskey Advanced Lead Development - Just How Complex Does if Need to be
1:00 – 1:30 p.m. B. Pirotte The Use of SUR1/Kir6.2-Selective Potassium Channel Openers in the Treatment of Endocrine Metabolic Disorders Associated with Hyperinsulinemia : Recent Developments and Future Prospects
1:30 – 2:00 p.m. L. Prokai Brain-Selective Estrogen Therapy

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: E. Arinc Co-Chairman: M. Lee
12:30 – 1:00 p.m. M. Sinz Predicting Enzyme Induction and Drug-Drug Interactions
1:00 – 1:30 p.m. R. Weaver Challenging R&D Paradigms by Use of Microdose and Microtracer Studies During Non-Clinical Development and Beyond
1:30 – 2:00 p.m. M. Barton Novel Aspects of Estrogen Receptor Signaling for Vascular Disease and Therapy

Location: Umm Al Quwain Hall (Upstairs)

Chairman: S.T. Furlong Co-Chairman: C. Assaf
12:30 – 1:00 p.m. H. Kasuya Future Development of Oncolytic Virus Therapy
1:00 – 1:30 p.m. A.J. Melendez Sphingosine Kinases Emerging Therapeutic Targets in Inflammation and Allergy
1:30 – 2:00 p.m. E. Prossnitz GPR30 as a Novel Biomarker and Drug Target

LUNCH BREAK : 2:00 – 3:30 p.m.

Location: Sheikh Rashid Hall B

Chairman: W. Banks Co-Chairman: A. Kalgutkar
3:30 – 3:50 p.m. A. Kamel The Role of Aldehyde Oxidase in the Metabolism of the Antipsychotic Drug Geodon
3:50 – 4:10 p.m. H. Hassan Regioselective Synthesis of Symmetric Pyridine-Spaced Sulfated Glucuronic Acid and Study of Their Antiproliferative Activity
4:10 – 4:30 p.m. A. Martinez From Rational Drug Design To Disease Modifying Drugs For Alzheimer´s Disease

Location: Sheikh Rashid Hall C

Chairman: A. Mjalli Co-Chairman: J.M. Brunel
3:30 – 3:50 p.m. J. Chin-Dusting The Heterogeneity of High Density Lipoproteins: Implications for Therapeutic Development.
3:50 – 4:10 p.m. C.-H. Chen New Drug Development following Characterization of a Novel Atherogenic Lipoprotein
4:10 – 4:30 p.m. C. Szabo Development of Gaseotransmitters (Nitric Oxide, Carbon Monoxide, Hydrogen Sulfide) as Pharmaceutical Agents: Past Challenges, Future Opportunities

 

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: F. Maina Co-Chairman: B. Zacharie
3:30 – 3:50 p.m. K. Ogata Regulatory Mechanism of Assembly of Transcription Factors on DNA
3:50 – 4:10 p.m. G. Kleymann Discovery of New Drugs and Innovative Therapeutic Principles for Superior Treatment of Herpes Disease
4:10 – 4:30 p.m. P. Yu Vascular Surface Semicarbazide-Sensitive Amine Oxidase (SSAO/VAP-1) as a Novel Target for Treatment of Chronic Vascular Disorders Associated with Protein Misfolding and Inflammation

Location: Umm Al Quwain Hall (Upstairs)

Chairman: A. Bernkop-Schnuerch Co-Chairman: M. Roberts
3:30 – 3:50 p.m. R. Alany Corneal Delivery and Stability of Connexin 43 Antisense Oligonucleotides
3:50 – 4:10 p.m. S. Al-Assaf Controlling the Physicochemical Properties of Polysaccharides and Proteins
4:10 – 4:30 p.m. J. Blanchfield The Development of Polymer Based Synthetic Vaccines

COFFEE BREAK : 4:30 – 5:00 p.m. (Sheikh Rashid Hall B)

LOCATION : Sheikh Rashid Hall B

Chairman: S. Nwaka Co-Chairman: T. Rades
5:00 – 5:20 p.m. J. Du Plessis Transdermal Delivery of Arginine Vasopressin with Pheroid™ Technology
5:20 – 5:40 p.m. R. Falconer Selective Delivery of Anti-Tumour Agents via Matrix Metalloproteinase (MMP)-Cleavable Peptides
5:40 – 6:00 p.m. M. Foldvari Prospects for Non-Invasive Delivery of Proteins and Nucleic Acids Across the Skin
6:00 – 6:20 p.m. S. Celikoglu A New Paradigm for Cancer Chemotherapy: Intratumoral Drug Delivery
6:20 – 6:40 p.m. M. Kuzuya A Novel Drug Engineering by Plasma Technique
6:40 – 7:00 p.m. R. Pasqualini/W. Arap Ligand-Directed Therapy and Molecular Imaging based on In Vivo Phage Display Technology

LOCATION : Sheikh Rashid Hall C

Chairman: J. Gibbins Co-Chairman: K. Hostetler
5:00 – 5:20 p.m. K. Pankiewicz NAD-based Anticancer Therapeutics
5:20 – 5:40 p.m. M.A. Abdullah Cell Engineering and Molecular Pharming for Biopharmaceuticals
5:40 – 6:00 p.m. M. Walter High Throughput X-ray Crystallography: Feeding the Drug Discovery Pipeline
6:00 – 6:20 p.m. Z. Witczak Thio-sugars as Emerging Targets for Carbohydrate Therapeutics Discovery
6:20 – 6:40 p.m. T. Al Tel Diversity-Oriented Synthesis: Enantioselective Synthesis of a Pool of Small Molecules as Drug Candidates
6:40 – 7:00 p.m. A. Peracchi How (and why) to revive a dead enzyme: the power of chemical rescue

LOCATION : Ras Al Khaimah Hall (Upstairs)

Chairman: M. Searcey Co-Chairman: J. Jimeno
5:00 – 5:20 p.m. N. Zgheib The Effect of Liver Disease on Cytochrome P450 Mediated Metabolism
5:20 – 5:40 p.m. V. Brabec Platinum Coordination Complexes. from DNA Interactions to New Anti-Tumor Drug Design
5:40 – 6:00 p.m. I. Gockel Novel Therapeutic Targets in Esophageal Cancer: Impact of Coexpression of Receptor-Tyrosine-Kinases (RTK) and Chemokine Receptor CXCR4
6:00 – 6:20 p.m. R. Kiss The Sodium Pump and Its Alpha1 and Alpha3 Subunits as Novel Targets to Combat Apoptosis- and/or Multidrug-Resistant Proliferating and Migrating Cancer Cells
6:20 – 6:40 p.m. V. Djonov
Title Awaited
6:40 – 7:00 p.m. A. Pertis Non-Natural Nucleotide Analogs as Probes of DNA Polymerase Activity

LOCATION : Umm Al Quwain Hall (Upstairs)

Chairman: H. Renz Co-Chairman: A. Khalid
5:00 – 5:20 p.m. A. Ali Discovery of Novel, Selective Glucocorticoid Receptor Modulators
5:20 – 5:40 p.m. R. Assaly Plasma Expansion by Polyethylene Glycol Modified Albumin (PEG-Alb)
5:40 – 6:00 p.m. L. Chugh Dengue Virus Viremia: Role of NS1 Protein of Virus / Cytotoxic Factor Produced by T-Cells
6:00 – 6:20 p.m. J. De Sanctis New Glutarimide Alkaloids as Potent Anti-Inflammatory Drugs
6:20 – 6:40 p.m. C.D. Ribas Relevant Effects of Omalizumab, an Anti-Ige Drug, In Asthma and other Diseases
6:40 – 7:00 p.m. P. Sayeski Jak2 and Reactive Oxygen Species: A Complex Relationship

LOCATION: Sheikh Rashid Hall A
POSTER SESSION : 6:00 – 7:00 p.m.


Thursday, February 7, 2008

Location: Sheikh Rashid Hall B

Chairman: M. Waring Co-Chairman: P. Herdewijn
Time Name of Speaker Title
8:30 – 9:00 a.m. J. Jimeno The Development of Marine Derived Anticancer Agents in the Era of Targeted Therapies
9:00 – 9:30 a.m. L. Khachigian Targeting Key Transcription Factors in Various Experimental Cardiovascular Pathologies
9:30 – 10:00 a.m. M. Searcey Targeting the Holliday junction: A New Target for Cancer Research?
10:00 – 10:30 a.m. K. Geckeler Supramolecular Anticancer Drugs: From Design to Reality

Location: Sheikh Rashid Hall C

Chairman: A. McCluskey Co-Chairman: L. Prokai
8:30 – 9:00 a.m. H. Lashuel Protein Misfolding and Fibrillogenesis in Neurodgenerative Diseases: From Mechanistic Studies to Therapeutic Strategies
9:00 – 9:30 a.m. C. McCurdy Sigma Receptor Ligands as Pharmacotherapy for Psychostimulant Abuse
9:30 – 10:00 a.m. E. Marechal Screening for Drugs with Herbicidal, Algicidal and Antiparasitic properties: a novel Paradigm to Discover new Antimalarial Compounds
10:00 – 10:30 a.m. A. Mjalli The Use of TTP Translational Technology to Discover Novel Treatments for Alzheimer's Disease, Cardiovascular Diseases & Diabetes

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: M. Barton Co-Chairman: S. Ingvarsson
8:30 – 9:00 a.m. T. Ruckle PI3Kγ and PI3Kδ Partners in Crime in Inflammation? Rheumatoid Arthritis and Beyond
9:00 – 9:30 a.m. K. Tsuji Differential Production of Connective Tissue-Type and Mucosal Mast Cells from Human Embryonic Stem Cells for Anti-Allergy Drug Screening
9:30 – 10:00 a.m. R. Wallis Assessing the Infection Risks of New Anti-Inflammatory Therapies
10:00 – 10:30 a.m. T. Takahashi Prevention of Cardiovascular Diseases by Regulation of Endothelial Cell-Neutrophil-Cytokine Interaction

Location: Umm Al Quwain Hall (Upstairs)

Chairman: A.J. Melendez Co-Chairman: H. Kasuya
8:30 – 9:00 a.m. I. Shcherbakova How to Learn Lessons from Failures: Discovery and Development of Novel Neuronal L-Type Calcium Channel Blockers
9:00 – 9:30 a.m. G. Semple Discovery of MK-0354: a Niacin Receptor Partial Agonist with Acute Antilipolytic Activity but Little Flushing Effect in Preclinical Species and in Humans
9:30 – 10:00 a.m. M. P. Costi Interfering with Human Thymidylate Synthase Dimerization: a Strategy for Folate pathway down Regulation in Platinum Resistant ovarian Carcinoma
10:00 – 10:30 a.m. S. Tkachenko Discovery and Development of Orally Bioavailable 5-HT6 Receptor Antagonists for Cognition Enhancement in Treating Alzheimer’s Disease. Fingerprinting Approach to Clinical Candidates. Parallel Optimization in “Constellation” of CNS Targets

COFFEE BREAK : 10:30 – 11:15 a.m. (Sheikh Rashid Hall D)

Location: Sheikh Rashid Hall B

Chairman: T. Al Tel Co-Chairman: K. Tsuji
11:15 – 11:45 a.m. K. Strebhardt Perspectives of Novel ATP- and Non-ATP-Competitive Kinase Inhibitors: Targeting Polo-Like Kinase 1 for Anticancer Therapy
11:45 – 12:05 p.m. G. Leclercq Implication of Estrogen Receptor α in Breast Cancer Development - A New Concept for the Development of Drugs Aimed to Antagonize its Action
12:05 – 12:25 p.m. C.-T. Lin Peptide-Targeted Chemotherapy against Nasopharyngeal Carcinoma
12:25 – 12:45 p.m. S. Linder A Biomarker Concept for Anticancer Drug Development
12:45 – 01:05 p.m. N. Eikje Identification and Characterization of Skin Biomolecules for Drug Targeting by Vibrational Spectroscopy

Location: Sheikh Rashid Hall C

Chairman: M. Honan Co-Chairman: T. Takahashi
11:15 – 11:45 a.m. A. Haoudi A New Era of Medicine “Genomic Medicine”: Connecting Genes, Drugs and Diseases
11:45 – 12:05 p.m. Y.-C. Kuo The Immunomodulatory Activities of (S)-Armepavine on Autoimmune Diseases In vivo and In vitro
12:05 – 12:25 p.m. W. Chegwidden The Carbonic Anhydrases: Potential Therapeutic Targets in Renal Carcinoma
12:25 – 12:45 p.m. G.B. Fields Mechanism and Inhibition of Collagenolytic Matrix Metalloproteinases
12:45 – 01:05 p.m. S. Qureshi Improved In vitro Model to Assess Drugs Release Characteristics of Products for their Absorption from Human Gastrointestinal Tract

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: H. Lashuel Co-Chairman: R. Wallis
11:15 – 11:45 a.m. X. Morelli From Virtual Screening to Experimental data: A Foursome to Inhibit Protein-Protein Interaction involving nef from HIV
11:45 – 12:05 p.m. B. Imbimbo The Therapeutic Potential of γ -Secretase Modulators in Treating Alzheimer’s disease
12:05 – 12:25 p.m. M. Botta The Fight against AIDS: New Avenues for Inhibiting RT, an Old Target
12:25 – 12:45 p.m. T. Prisinzano Discovery of mu Opioids with altered Receptor Regulation
12:45 – 01:05 p.m. N. Zawia A Novel class of Mechanism-based Drugs for the Treatment of Alzheimer’s Disease

Location: Umm Al Quwain Hall (Upstairs)

Chairman: Z. Witczak Co-Chairman: Y. Al Abed
11:15 – 11:45 a.m. L. Ghosez Synthesis: A Creative Engine for Drug Discovery and Development
11:45 – 12:05 p.m. U. Holzgrabe Piggy Back Approach: Bisaphthalimides As Muscarinic Agnoists, Cancerostatics, And Antiinfectives
12:05 – 12:25 p.m. R. James Developing Novel Antimicrobial Peptides Active Against Gram-Positive Pathogens
12:25 – 12:45 p.m. L. Polonelli Engineered Antibody Cdrs As Novel Antimicrobial, Antiviral And Antitumor Drugs
12:45 – 01:05 p.m. C. Salmi Squalamine, A New Antibiotic Extracted From Marine Environment: How about Its Mechanism Of Action With Respect to Gram-Negative Bacteria?

LUNCH BREAK : 1:05 – 2:15 p.m.

Location: Sheikh Rashid Hall B

Chairman: L. Khachigian Co-Chairman: G. Semple
2:15 – 2:45 p.m. H.H. Fiebig Gene Signatures Predicting Tumor Response to Cytotoxic Drugs
2:45 – 3:15 p.m. H. Cheradame Can the Block Copolymers Hurdle the Whole Process of DNA Transfer?
3:15 – 3:35 p.m. M. Alam High Throughput Compound Library Screening for Potential Antiviral Drugs for Dengue Virus
3:35 – 3:55 p.m. K.-I. Sato Focused Proteomics on Membrane Microdomain-associated Signal Transduction in Fertilized Amphibian Eggs and Human Bladder Carcinoma Cells
3.55 – 4:15 p.m. P. Aljama Optimizing the Use of Erythropoiesis Agents (ESA) in Renal Anemia

Location: Sheikh Rashid Hall C

Chairman: C. Prakash Co-Chairman: M. Costi
2:15 – 2:45 p.m. A. Ashkar Targeting the innate immune system to fight infection
2:45 – 3:15 p.m. R.M. Fusaro The Maillard Reaction for Melanoidins-Sunscreen Formation: New Technical Standards Needed to Evaluate Effectiveness
3:15 – 3:35 p.m. A. Pini Identification, Optimization and In vivo Activity of a Branched Antimicrobial Peptide Selective For Gram-Negative Bacteria
3:35 – 3:55 p.m. H.-M. Chen Structure of a Novel Anticancer Peptide CB1a, Based on the N-terminal Peptide Sequence of Cecropin B
3.55 – 4:15 p.m. L.-K. Chau Rapid and Label-Free Bio-Detection Based on Localized Plasmon Resonance

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: K. Geckeler Co-Chairman: I. Ojima
2:15 – 2:45 p.m. Y. Wang Developing Novel Anti-inflammatory Therapy for Asthma/COPD
2:45 – 3:15 p.m. C. Freund Proline-Rich Sequence Recognition: Principles and Molecular Interference
3:15 – 3:35 p.m. D. Steinbach Which ABC-transporters should we target in Leukemia?
3:35 – 3:55 p.m. E. Terpos Proteasome Inhibition Therapies and Bone Metabolism in Multiple Myeloma
3.55 – 4:15 p.m. M. Turkay Identification of Drug Candidates for Prostate Cancer Using Computational and Experimental Methods

Location: Umm Al Quwain Hall (Upstairs)

Chairman: S.S. Sabri Co-Chairman: T. Ouchi
2:15 – 2:45 p.m. M. Suzuki An Efficient, General Synthesis of 11C- and 18F-incorporated PET Tracers Toward Revolutionizing Drug Development and Diagnosis
2:45 – 3:15 p.m. B. Zacharie Triazine Derivatives as Protein A Mimetics for the Treatment of Autoimmune Disease
3:15 – 3:35 p.m. S. Shigeta Anti-RNA Virus Activity of Polyoxometalates
3:35 – 3:55 p.m. D. Buchi Immune System Modulation with a Homeopathic Medication.
3.55 – 4:15 p.m. W. Childers Serotonergic Drug Design - Finding Diamonds in the Rough

COFFEE BREAK : 4:15 – 5:00 p.m. (Sheikh Rashid Hall D)

Location: Sheikh Rashid Hall B

Chairman: A. Ashkar Co-Chairman: J. St-Amand
5:00 – 5:20 p.m. Y. Collette HIV-1 nef-SH3 Targeting as a Proof of Concept for the Development of Anti-Viral Protein-Protein Interaction Inhibitors
5:20 – 5:40 p.m. E. Elzein Discovery of CVT-6883: A Novel A2B Adenosine Receptor Antagonist as a Clinical Candidate for the Treatment of Asthma
5.40 – 6:00 p.m. A. Grobler Pheroid TM Technology: A Novel Drug Delivery System with Broad Application
6:00 – 6:20 p.m. B.Noszal Molecular Mechanism of Morphine-6-Glucuronidate Brain Penetration
6:20 – 6:40 p.m J.O.V. Planells Transcorneal Permeation of Nsaids Drug Delivery in a Corneal Device
6:40 – 7:00 p.m. S.E. Mansour Synthesis and Antimicrobial Activity of some Novel Oxadiazole Derivatives

Location: Sheikh Rashid Hall C

Chairman: M. Sinz Co-Chairman: E. Prossnitz
5:00 – 5:20 p.m. A. Damas TTR Amyloidosis: from the Molecular Mechanism to Therapy
5:20 – 5:40 p.m. K. Filipiak How can we Prevent Diabetes in Pharmacological way ?
5.40 – 6:00 p.m. H. Kang Peroxisome Proliferator-Activated Receptor Delta Selective Agonists as Potent Anti-Atherogenic Agents In vivo
6:00 – 6:20 p.m. J. Zablocki Novel Aldehyde Dehydrogenase-2 Inhibitors as a Potential Treatment of Alcohol Addiction
6:20 – 6:40 p.m C. Assaf Emerging Drugs in Cutaneous Lymphomas
6:40 – 7:00 p.m. S. Kumar Can the Acute Toxicity of Antidepressants be Predicted Using the Protozoan Tetrahymena pyriformis?

Location: Ras Al Khaimah Hall (Upstairs)

Chairman: E. Marechal Co-Chairman: K. Strebhardt
5:00 – 5:20 p.m. D. Dizon From Bench to Bedside: The clinical development of pertuzumab in women's cancers
5:20 – 5:40 p.m. M. Gyongyossy-Issa A synthetic platelet as application of a targeted controlled-rate drug delivery vehicle
5.40 – 6:00 p.m. H.-G. Ljunggren Prospects for the Use of NK-Cells in Immunotherapy Against Human Cancer
6:00 – 6:20 p.m. G.-J. Wang Endotoxin-Stimulated Responses and Therapeutic Herbal Medicines Development by a Systems Biology Approach
6:20 – 6:40 p.m. M.J. Drysdale Structure Based Discovery of Hsp90 Inhibitors for the Treatment of Cancer
6:40 – 7:00 p.m B. Ahmed Antihypertensive, Cardiovascular and β-Blocking Adrenergic Activity of Aryloxypropanolamines

Location: Umm Al Quwain Hall (Upstairs)

Chairman: H. Kurumizaka Co-Chairman: Y. Wang
5:00 – 5:20 p.m. A. El-Dahshan An Efficient Solid Phase Synthesis Concept for the Preparation of various Novel Biologically Active Peptide Mimetics
5:20 – 5:40 p.m. E. Goldsmith Unique Autoinhibitory Dimers in the MAP2K MEK6, and MAP4K OSR1
5.40 – 6:00 p.m. R. Scott
Title awaited
6:00 – 6:20 p.m. M. Shamssain Novel Strategies for the Treatment of Asthma and COPD - Future Challenges of Drug Therapy
6:20 – 6:40 p.m H.H.A.-M. Hassan Regioselective Synthesis of Symmetric Pyridine-Spaced Sulfated Glucuronic Acid and Study of their Antiproliferative Activity
6:40 – 7:00 p.m. R. Howes Development of Inhibitors of Hsp90 for Cancer Therapy: The Screening Story

LOCATION: Sheikh Rashid Hall A
POSTER SESSION : 6:00 – 7:00 p.m.

LOCATION: Sheikh Rashid Hall B
Closing Ceremony : 7:00 - 7:30 p.m.

LOCATION: Sheikh Rashid Hall D
Refreshment : 7:30

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