The 1st International Conference on Drug Design & Discovery: Dubai, February 3 - 6, 2008

Drug Delivery

Istvan Toth, University of Queensland, Australia
Istvan Toth - CV - PDF

Many biologically active molecules are very active in vitro, but never reach the clinic because of lack of absorption and/or poor in vivo stability. Although a range of delivery systems is available, the delivery of sensitive drugs such as peptides, nucleic acid based therapeutics (including antisense DNA and siRNA), simple and complex carbohydrates, and synthetic vaccines presents a major challenge to the pharmaceutical industry. Industry experts agree that approximately 10% of the costs of drug development program should be allocated to aspects of drug delivery. New developments in drug delivery research are likely to have enormous economic impacts upon the pharmaceutical and biotechnology industries. In fact, drug delivery research represents a US$70 billion a year industry. Centres for Drug Delivery have been established all over the world to promote research, development and training in drug delivery science. There has also been a focus on realizing the commercial potential of innovative molecules (e.g. peptides, nucleic acid based therapies and vaccines) or delivery technologies that are developed from the centres’ research. Research in drug delivery is multidisciplinary, requiring knowledge of how drugs work, their chemical and physical properties, how these properties affect the drugs in vivo behaviour, and what could be done to potentially solve any delivery problems associated with drug molecules. Therefore, drug delivery research necessitates interdisciplinary collaborations both at a national and international level.

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